DNA – Page 4 – TechConnect Briefs

Using Electron Tunneling for Direct Sequencing of DNA

Lund J., Dong J., Mehta R., Rahimi M., Ryan D., Parviz B.A., University of Washington, US

Genomic information has assumed a central role in the way biology in general and cell function in particular are understood today. Methods that can sequence DNA rapidly, accurately, and cost-effectively are needed in order to [...]

Electronic DNA detection on semiconductor surfaces

Han Y., Tan E., Candebat D., Bandyopadhyay K., Niemz A., Keck Graduation Institute, US

Electronic biosensors offer a viable alternative to optical biosensors for the rapid, specific, and sensitive detection of DNA. We are utilizing an electrolyte-oxide-semiconductor (EOS) biosensor system on a SiO2/Si surface for impedimetric detection of DNA. [...]

Nanomechanical Cantilever Bio-Sensors for Time-Resolved Detection of DNA and Surface Layer Formation

Bammerlin M., Köser J., Shahgaldian P., Pieles U., Battiston F.M., Hubler U., Concentris GmbH, CH

Nanomechanical cantilever are small and extremely sensitive force and mass detectors. By coating (functionalizing) their surface with specific receptor molecules, cantilevers can be converted into highly sensitive and selective chemical sensors or label-free biosensors. The [...]

Single Base Mismatch Determination using DNA – Silver Nanoparticle Conjugates

Thompson D., Faulds K., Smith W.E., Graham D., University of Strathclyde, UK

Modification of oligonucleotides with gold nanoparticles was first reported ten years ago and opened up several new avenues of research as they can be used as a novel nanostructured building material but the conjugate can [...]

Comparison of the Efficiency of Different Methods for the Lysis of Cells in Lab-on-Chip Systems

Drese K., von Germar F., Roesser T., Hansen-Hagge T., Bullema J., Bolt P., TNO Science and Industry, NL

Many diagnostic or analytical tasks are based on detection of specific amplificates of DNA or RNA. Lab-on-Chip systems are developed for such tests because often only small sample volumes and analyte concentrations are available. A [...]

Interaction of DNA with Single-Walled Carbon Nanotubes: Implication to the Bio-Sensors

Kong K-J, Chang H., Lee J-O, Korea Research Institute of Chemical Technology, KR

Here, we have briefly introduced the recent progresses in experiments of DNA sensing with CNT-FET sensors and theoretical investigations to explore the sensing mechanism.

Nanofabrication of Biomaterial, CNT and Organic Polymer Patterned Thinfilms using Piezoelectric Ink Jet Printing

Sumerel J.L., Deravi L.F., Wright D.W., Dimatix, Inc., US

In contrast to thermal ink jetting that uses heat to generate fluid drop ejection, MEMS-constructed piezoelectric ink jet printheads use a thin PZT slab bonded to a silicon diaphragm to generate acoustic energy that drives [...]

Electric Field Process for the Fabrication of Higher Order Structures form Biomolecule Derivatized Nanoparticles

Heller M.J., Dehlinger D., Sullivan B., Esener S., University of California San Diego, US

An electronic microarray has been used to carry out directed self-assembly of higher order 3D structures from Biotin/Streptavidin and DNA derivatized nanoparticles. Structures with up to fifty layers of alternating biotin and streptavidin and DNA [...]

DNA Extraction with Parallel Electrodes on Microfluidic System

Parng S.H., Shia T.K., Yang H.J., Kuo C.H., Microsystem Technology Common Laboratory, TW

DNA trapping was demonstrated between an electrical field across two parallel integrated electrodes on chip fabricated by the MEMS techniques. The method to release the trapped DNA molecules using reversed voltage control electrical field was [...]

A Lab-on-a-Chip using Magnetic Droplets

Lehmann U., Parashar V.K., Vandevyver C., Gijs M.A.M., EPFL, CH

We present a chip-based bio-analysis system using the two dimensional (2D) magnetic manipulation of microdroplets. The latter contain magnetic microparticles which serve as force mediators for the droplet actuation. In combination with a changeable field [...]