Large scale Manufacturing of Calcium Phosphate Nanoparticles for Medical Applications


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Calcium phosphate (CaP) nanoparticles find medical applications in a number of areas, including delivery of nucleic acid therapeutics and calcium-based tissue engineering. CaP is well-studied biocompatible, bioactive, and bioabsorbable material and is used extensively in laboratory settings. However, current methods to produce CaP nanoparticles are laboratory based, inefficient, often require harsh organic solvents, and result in particles that readily agglomerate. Delphi Scientific, LLC has employed a continuous, GMP compatible, process and unique formulations to produce CaP-RNA particles. Batches of uniform particles below 200 nm and as low as 35 nm were produced. The particles were readily filter sterilazable, which is a requirement for many drug delivery applications and were fairly stable for a few days. SAXS analysis revealed particles with a core at about 35 nm and corroborated these findings. The particles were stable for at least 24-48 hrs.

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Journal: TechConnect Briefs
Volume: TechConnect Briefs 2021
Published: October 18, 2021
Pages: 58 - 61
Industry sector: Advanced Materials & Manufacturing
Topics: Advanced Materials for Engineering Applications, Materials Characterization & Imaging
ISBN: 978-0-578-99550-2