digital microfluidics – TechConnect Briefs

Companion diagnostic test using digital microfluidic

Fouillet Y., Den Dulk R., Fuchs O., Boizot F., Menneteau M., Navarro F., CEA-LETI, FR

Companion diagnostics are an indispensable part of personalized medicine, providing information that is essential for the safe and effective use of a corresponding therapeutic drug. Such devices need to be robust, transportable and easy to [...]

Droplet actuation on a digital microfluidic chip using a 5 volt battery

Rezaei Nejad H., University of British Columbia, CA

This paper presents a circuit using a 5-volt DC battery to actuate droplets on a DMF chip. The output of the circuit is a controllable high voltage, high frequency AC signal which can actuate a [...]

Droplet Dispensing from Open to Close Digital Microfluidics

Rezaei Nejad H., University of British Columbia, CA

There are two types of DMF platforms: open and closed systems. Each platform has its own advantages. For instance, it is easier to access the droplet in the open systems; whereas, the closed system limits [...]

Introducing a Digital Micropump for Driving a Droplet in a Microfluidic Channel

Rezaei Nejad H., University of British Columbia, CA

This paper presents a novel pumping technique which is compatible with both digital and continuous microfluidic platforms. In essence, a target droplet (referred to as the pumped droplet) is pumped by actuating the secondary droplet [...]

Experimental investigation of the possibility of transporting a droplet over a hydrophilic spot in digital microfluidics

Samiei E., Hoorfar M., University of British Columbia, CA

This paper studies the transport of a water droplet over a hydrophilic spot (representing the sensing surface of a biosensor) created on the top plate of a digital microfluidic chip. For this purpose, a closed [...]

Determination of droplet shape in digital microfluidic systems using two-dimensional flow analysis

Ahmadi A., Najjaran H., Holzman J.F., Hoorfar M., University of British Columbia Okanagan, CA

A two-dimensional model for fluid flow in a digital microfluidic system is introduced, and the results are compared to experimental data. Resistive flow effects based upon contact line forces, filler effects and shear forces are [...]

Modeling microdrop motion between covered and open regions of EWOD microsystems

Berthier J., Clementz Ph., Roux J-M, Fouillet Y., Peponnet C., CEA-LETI, FR

Digital microfluidics is a promising way to manipulate biological targets like DNA, proteins or cells in very small liquid volumes. The advantages of such devices are the use of lesser quantities of costly reagents, better [...]

An Analytical Model for the Prediction of Microdrop Extraction and Splitting in Digital Microfluidics Systems

Berthier J., Raccurt O., Clementz Ph., Jary D., Claustre P., Peponnet C., Fouillet Y., CEA-LETI, FR

In the preceding text submitted to Nanotech 2005, we have demonstrated that surface tension is the dominant force on liquid microdrops in EWOD microsystems and that the problem is mostly topological. Minimization of the surface [...]