Cerebrolysin – TechConnect Briefs

TiO2 nanowired delivery of cerebrolysin induces superior neuroprotection following exacerbation of blast brain injury pathophysiology in diabetes

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Nozari A., Patnaik R., Nozari A., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., University of Medicine and Pharmacy "Iuliu Hatieganu", Cluj-Napoca, Romania, RO

Blast brain injury (bBI), a combination of pressure, rotation, penetration of sharp objects and chemical exposure is prevalent in military personnel during combat operations causing laceration, perforation and tissue loss in the brain. Since combat [...]

Intraspinal administration of TiO2 nanowired cerebrolysin with mesenchymal stem cells has superior neuroprotective effects on cord pathology and functional outcome following a focal spinal cord trauma

Feng L., Sharma A., Sharma H.S., Niu F., Huang H., Lafuenta J.V., Muresanu D.F., Ozkizilcik A., Tian Z.R., Sharma A., Sharma H.S., Bethune International Peace Hospital, CN

Military personnel are often victims of spinal cord injury (SCI) for which there is no suitable treatment available. Thus, exploring new therapeutic avenues using select combination of novel neuroprotective agents is the need of the [...]

Co-administration of TiO2 nanowired cerebrolysin and alpha melanocyte stimulating hormone has superior neuroprotective effects on brain pathology following concussive head injury after sleep deprivation

Sharma A., Sharma H.S., Lafuente J.V., Muresanua D.F., Nozari A., Patnaik R., Tian Z.R., Ozkizilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, Uppsala, SE

Sleep deprivation (SD) is common in military personnel engaged in combat operations. Our previous reports show that 12 h SD alone induces brain pathology and continued until 72 h in a progressive manner. However, these [...]

Exacerbation of amyloid beta peptide and Tau protein in the cerebrospinal fluid following Traumatic Brain Injury at Hot Environment. Neuroproetction by TiO2 nanowired delivery of cerebrolysin with tau antibodies

Sharma A., Sharma H.S., Lafuente J.V., Muresanua D.F., Castellani R.J., Smith M.A., Nozari A., Patnaik R., Tian Z.R., Ozkizilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, Uppsala, SE

Military personnel are often exposed to high environmental temperature in desert areas during combat operations. Since traumatic brain injury (TBI) is quite common in combat operation, a possibility exists that hot environment (HE) could affect [...]

Neuroprotective effects of cerebrolysin in exacerbation of blood-brain barrier breakdown, neuropathology and upregulation of nitric oxide synthase and hemeoxygenase in diabetes and hypertension after heat stroke

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Nozari A., Patnaik R., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., Iuliu Hatieganu University of Medicine and Pharmacy, RO

Military personnel are often exposed to heat stress in desert areas either during peacekeeping or combat operations. In such situations, they are quite vulnerable to heat stroke and brain pathology. Due to severe work stress [...]

Timed release of cerebrolysin using titanate nanospheres induces neuroprotection in Parkinson’s Disease

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Ozkizilcik A., Tian Z.R., Patnaik R., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Military personnel during combat operations are highly susceptible to traumatic brain and spinal cord injury. There are reasons to believe that a focal injury to the central nervous system (CNS) causes multiple biochemical and pathological [...]

Nanodelivery of drugs for therapeutic strategies in CNS disorders. Current and Future perspectives

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Nanodelivery of drugs, diagnostic agents and other functionalized nanoparticles aiming for better treatment of diseases or diagnosis purposes are the new trends in medicine that appear promising. However, nanoparticles or nanotechnology used to deliver these [...]

TiO2 Nanowired Cerebrolysin reduces neuron-specific ubiquitin carboxyl-terminal esterase-L1 (UCHL1) in Alzheimer’s Disease and brain pathology

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., University of Medicine & Pharmacy, RO

Our military personnel during combat operations are vulnerable to various kinds of traumatic brain injuries. These soldiers are prone to develop neurodegenerative diseases e.g., Alzheimer’s Disease (AD) over time. Thus, efforts should be made to [...]

Nanodelivery of Cerebrolysin Induces Profound Neuroprotection in Heat Stroke Following Chronic Hypertension in Combination with SiO2 and Carbon Nanoparticles Induced Exacerbation of Brain Damage

Muresanu D.F., Sharma A., Sharma H.S., Patnaik R., Nozari A., Mössler H., Tian Z.R., Ozkizilcik A., Sharma A., Sharma H.S., Uppsala University, SE

Our military personals are often exposed to combat stress induced hypertension in an environment rich in various nanoparticles emanating from different sources e.g., gun powder explosion or blast injuries. Furthermore, combat or peacekeeping activity in [...]

Nanodelivery of Cerebrolysin as adjunct therapy with Functionalized magnetic iron oxide nanoparticles enhances neuroprotection

Sharma A., Sharma H.S., Muresanu D.F., Tian Z.R., Moessler H., Sharma A., Sharma H.S., Uppsala University, SE

1. Functionalized magnetic iron oxide nanoparticles (FMIONPs) are used as adjunct therapy in cancer to effectively enhance cellular damages of cancerous cells sparing normal cells using chemotherapy or heat treatment. The FMIONPs are considered safe. [...]