cells – Page 2 – TechConnect Briefs

The Nucleolus and Cellular Stress: Analysis by Coherent Phase Microscopy

Tychinsky V.P., Kretyshev A.V., Klemyashov I.V., Reshetov I.V., Vyshenskaya T.V., Shtil A.A., P.A.Hertsen Moscow Research Oncological Institute, RU

Coherent phase microscopy is a nanoscale measurement technique, an original method of monitoring the responses to cellular stress. We demonstrate that: 1) optically dense subcellular structures, including the nuclei and nucleoli, can be clearly detected [...]

Flat Fluidics: Programmable On-Chip Networks for Biological and Chemical Applications

Wixforth A., University of Augsburg and Advalytix AG, DE

We present a novel approach towards the needs of a versatile microfluidic chip-based microfluidic system with unique properties and functionality. Like for microarrays and in contrast to many existing microfluidic technologies, the fluid handling is [...]

Biomolecular Patterning via Photocatalytic Lithography

Bearinger J.P., Hiddessen A.L., Wu K.J.J., Christian A.T., Dugan L.C., Stone G., Camarero J., Hinz A.K., Hubbell J.A., Lawrence Livermore National Laboratory, US

We have developed a novel method for patterning surface chemistry: Photocatalytic Lithography. This technique relies on inexpensive stamp materials and light; it does not necessitate mass transport or specified substrates, and the wavelength of light [...]

A Microfluidic System for Continuous Magnetophoretic Separation of Suspended Cells Using Their Native Magnetic Properties

Han K-H, Bruno Frazier A., Georgia Institute of Technology, US

This paper presents the characterization of a continuous magnetophoretic microseparator for separating white and red blood cells from whole blood by using a high gradient magnetic separation method and microfabrication technology. The magnetophoretic microseparator directly [...]

Numerical Modeling of Diffusion in Extracellular Space of Biological Cell Clusters and Tumors

Berthier J., Rivera F., Caillat P., CEA-LETI, FR

Biological cluster of cells may be seen as porous media, where the cells are the “solid grains” and the extracellular space (ECS) the “pores”. It is often the case in dense clusters of cells that [...]