cancer – Page 2 – TechConnect Briefs

Hybrid biosensor for the early diagnosis of breast cancer

Cho K., Chong S., Lee J-H., Park E., Luminescent MD, LLC, US

A cost-effective and novel hybrid biosensor using the combination of antibody and DNA aptamer was developed for the early diagnosis of breast cancer. 1,1’-oxalyldiimidazle chemiluminescence (ODI-CL) was applied as a detector of the hybrid biosensor. [...]

pH Responsive Polymeric Nanoparticles Fabricated by Dispersion Polymerization as a Platform for the Delivery of Anticancer Drugs

Akala E., Berhe S., Puri R., Howard University, US

In diseased conditions such as tumors, pH is slightly more acidic than in the blood. The endocytic pathway of cells begin near the physiological pH of 7.4, but it drops to a lower pH of [...]

Metastatic diagnosis of colon cancer by vertically aligned carbon nanotube based electromechanical biosensor

Abdolahad M., Janmaleki M., Mohajerzadeh S., Taghinejad H., Taghinejad M., University of Tehran, IR

vertically aligned carbon nanotube based electrical biosensor was demonstrated as a more rapid, sensitive and specific device for metastatic diagnosis of colon cancer cells based on the mechanical entrapment of metastatic cancer cells on vertically [...]

Isolation and Detection of Cancer Related DNA Nanoparticulate Biomarkers Directly from CLL Patient Blood “Rapid Sample to Sequence Diagnostics”

Heller M.J., Marciniak J., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA biomarkers continues to become more widely used for cancer diagnostics and management. Cfc-DNA ranges from nucleosomes and high molecular weight DNA nanoparticulates to 100-200bp fragments. We have [...]

Gold-Coated Liposomes Encapsulating Signaling Molecules for Initiating Cellular Communication

Orsinger G.V., Romanowski M., University of Arizona, US

To better understand the complex communication pathways of the tumor microenvironment, and therefore better design and develop therapies and diagnostics for cancers, experimental methods of probing cellular communication at a single to multi-cell level are [...]

HDCR: A novel method for the diagnostic detection of methylated DNA for blood based cancer diagnostics

Ho T., Lindall C., Molloy P., Rand K., CSIRO, AU

We have developed a novel technique for specific amplification of rare methylated DNA fragments in a high background of unmethylated sequences that avoids the need of bisulphite conversion. The methylation-dependent restriction enzyme GlaI is used [...]

Drug Delivery with Light-Activated Gold-Coated Liposomes

Knights S.S., Leung S.J., Orsinger G.V., Romanowski M., Williams J.D., University of Arizona, US

With the ultimate goal of delivering therapeutic compounds selectively to cancerous or diseased tissues and cells, we have presented liposome-based plasmon resonant nanocapsules. The described biocompatible composite delivery vehicle enables encapsulation and selective release of [...]

Folate-Conjugated Gold Nanoparticles for Cancer Nanotechnology Applications

Brandenburg K.S., Mansoori G.A., Shakeri-Zadeh A., University of Illinois at Chicago, US

A need exists to target cancer treatments specifically to the tumor site, without damaging healthy tissue. This need can be achieved through the proper application of nanotechnology, namely gold nanoparticles conjugated to Folate. Folate is [...]

Plasmonic Nanobubbles as Tunable Theranostic Agents

Carson D.D., Constantinou P., Danysh D.S. Wagner B., Drezek R.A., Farach-Carson M.C., Hafner J.H., Lapotko D.O., Lukianova-Hleb E., Rice University, US

Plasmonic nanobubbles (PNB) were developed to support a cell level theranostics as the multi-functional, tunable and selective cellular probes. PNB is a transient and tunable vapor nanobubble that is generated on demand around overheated plasmonic [...]

New High Conductance DEP Devices for Detection of Cancer Related DNA Nanoparticulate Biomarkers and Nanoparticles in Whole Blood

Heller M.J., Sonnenberg A., University of California San Diego, US

The ability to rapidly detect cell free circulating (cfc) DNA nanoparticulate biomarkers, drug delivery nanoparticles and virus directly from blood is a major challenge for nanomedicine. We have now developed unique, simple and practical high [...]