breast cancer – TechConnect Briefs

Superparamagnetic relaxometry (SPMR) for sensitive detection of Her-2 positive tumors in mice

Paciotti G., Minser K.E., Weldon C.L., Gomez A., Karaulanov T., Hathaway H.J., Anderson W.H., Nettles C., Huber D.L., Vreeland E.C., Imagion Biosystems Inc., US

Superparamagnetic Relaxometry (SPMR) is a non-invasive technique that utilizes superconducting quantum interference device (SQUID) detectors to localize and quantify the magnetization of superparamagnetic iron oxide (Fe3O4) nanoparticles (NPs) specifically bound to cancerous tumors. In an [...]

Breast cancer diagnosis system using the combination of carcinoembryonic antigen aptamer, horseradish peroxidase-mimic hemin, and graphene sheet

Chong S., Cho K., Chong S., Khang H.J., Lee J-H., Lee S-Y, Kim Y.T., Lee J-H., Lee S-Y, Luminescent MD, LLC, US

In order to early diagnose breast cancer with the rapid quantification of carcinoembryonic antigen (CEA) in human serum, highly sensitive DNA aptasensor with 1,1-oxalyldiimidazole chemiluminescence (ODI-CL) detection was developed using the combination of CEA aptamer, [...]

Investigating the role of the FOXA1 protein in cancer with Scanning Probe Microscopy

Theodorou I., Imperial College London, UK

The FOXA1 protein has generated considerable interest for its use as a biomarker in breast cancer. In this project, the binding kinetics of FOXA1 with the BRCA1 and FOXC2 are investigated using Scanning Probe Microscopy. [...]

siRNA Delivery Using Biodegradable Nanoparticles for Breast Cancer Therapy

Abbasi S., Arghya P., Afshan K., Prakash S., McGill University, CA

Polyethylenimine (PEI)-coated human serum albumin (HSA) nanoparticles form suitable biocompatible carriers for therapeutic molecules. Small interfering RNA (siRNA) molecules have suggested great promise as a future therapy for breast cancer. In order to overcome the [...]

Bioluminescent Model for the Quantification of Photothermal Ablative Breast Cancer Therapy Mediated by Near-Infrared Nanoparticles

Gutwein L.G., Singh A.K., Hahn M.A., Rule M.C., Brown S.C., Moudgil B., Grobmyer S.R., University of Florida, US

Multifunctional nanoparticles hold promise for enabling non-invasive image guided cancer therapy such as photothermal therapy. Human breast tumor models in which response to image guided therapy can quickly and non-invasively be determined are needed to [...]

Epirubicin hydrochloride loaded poly (butyl cyanoacrylate) nanoparticles: formulation optimization, characterization and in vitro evaluation on human breast cancer cell lines

Dantuluri P.R., Shah N.M., Murthy R.S.R., Kumar M.R.S., Rao B.S.S., The M.S. University of Baroda, IN

Breast cancer is the second leading cause of deaths in women today after lung cancer, the mortality rate of patients with breast cancer around the world is rising steadily over time. Metastatic spread is the [...]

Treatment of Breast Cancer with Silver Antitumor Drugs Encapsulated in Biodegradable Polymeric Nanoparticles

Youngs J., Youngs W.J., Robishaw N., Panzner M.J., Hindi K., Medvetz D.A., Youngs J., Youngs W.J., Tessier C., Ditto A., Yun Y.H., Bauer J., Lindner D., University of Akron, US

Our research in cancer focuses on the development of silver carbene complexes (SCCs), for use as antitumor agents. We have found that SCCs have significant activity against a variety of cancers in vitro. Furthermore SCCs [...]

Landscape Phage Probes for Breast Cancer Cells

Fagbohun O.A., Bedi D., Jayanna P.K., Deinnocentes P.A., Bird R.C., Petrenko V.A., Auburn University, US

Landscape phage libraries are collections of filamentous phages displaying random foreign peptides on all 4,000 surface domains of the major coat protein. They serve as a rich source of bioselective materials that are used in [...]

Differential Uptake of PEG-Silica-FITC Nanoparticles by Human Breast Cancer Cells and Normal Human Breast Epithelial Cells

Iwakuma N., Sharma P., Delano M.J., Moldawer L.L., Moudgil B.M., Grobmyer S.R., University of Florida, US

Background: An understanding of uptake of nanoparticles (NPs) by human cancer cells and non-cancer cells is important for the development of NPs as novel cancer therapeutic and diagnostic agents. Hypothesis: Uptake of NPs is increased [...]

Detection of Live Breast Cancer Cells Using Carbon Nanotube Devices

Teker K., Cesarone G., Wickstrom E., Panchapakesan B., Frostburg State University, US

Development of new technologies for reliable early detection of cancer from biological fluids via minimally invasive methods is still a high priority. Cancer cells often overexpress characteristic surface receptors, which provide an opportunity for early [...]