Breast cancer diagnosis system using the combination of carcinoembryonic antigen aptamer, horseradish peroxidase-mimic hemin, and graphene sheet

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In order to early diagnose breast cancer with the rapid quantification of carcinoembryonic antigen (CEA) in human serum, highly sensitive DNA aptasensor with 1,1-oxalyldiimidazole chemiluminescence (ODI-CL) detection was developed using the combination of CEA aptamer, horseradish peroxidase (HRP)-mimic hemin, and graphene sheet in a polystyrene well. The accuracy, precision, and recovery of DNA aptasensor, capable of sensing CEA as low as 0.1 ng/ml, were good. Based on the research result, we confirmed that the novel DNA aptasensor can be applied as a new enzyme free analytical method for the early diagnosis of breast cancer.

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Journal: TechConnect Briefs
Volume: 1, Advanced Materials: TechConnect Briefs 2015
Published: June 14, 2015
Pages: 294 - 297
Industry sector: Advanced Materials & Manufacturing
Topic: Nanoparticle Synthesis & Applications
ISBN: 978-1-4987-4727-1