brain pathology – TechConnect Briefs

Co-administration of TiO2 nanowired cerebrolysin and alpha melanocyte stimulating hormone has superior neuroprotective effects on brain pathology following concussive head injury after sleep deprivation

Sharma A., Sharma H.S., Lafuente J.V., Muresanua D.F., Nozari A., Patnaik R., Tian Z.R., Ozkizilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, Uppsala, SE

Sleep deprivation (SD) is common in military personnel engaged in combat operations. Our previous reports show that 12 h SD alone induces brain pathology and continued until 72 h in a progressive manner. However, these [...]

Nanodelivery of cerebrolysin reduces functionalized Gold Nanoparticles induced Blood-brain barrier disruption, brain edema formation and brain pathology

Sharma A., Sharma H.S., Menon P.K., Muresanu D.F., Lafuente J.V., Nozari A., Patnaik R., Ozkizilcik A., Tian Z.R., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Recently, gold nanoparticles (AuNPs) are used for drug delivery in treating several neurological disorders e.g., Alzheimer’s disease (AD), Parkinson’s disease, Stroke and trauma. In addition, use of AuNPs for diagnostic purposes in various diseases are [...]

TiO2 Nanowired Cerebrolysin reduces neuron-specific ubiquitin carboxyl-terminal esterase-L1 (UCHL1) in Alzheimer’s Disease and brain pathology

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., University of Medicine & Pharmacy, RO

Our military personnel during combat operations are vulnerable to various kinds of traumatic brain injuries. These soldiers are prone to develop neurodegenerative diseases e.g., Alzheimer’s Disease (AD) over time. Thus, efforts should be made to [...]

Nanowired Mesenchymal Stem cells ameliorate brain pathology exacerbated by diabetes in hyperthermia

Sharma A., Sharma H.S., Feng L., Lafuente J.V., Muresanu D.F., Tian Z.R., Patnaik R., Sharma A., Sharma H.S., Uppsala University, SE

Stem cell transplantation or injection is associated with neuroprotection in stroke and in central nervous system (CNS) injury. However, role of stem cells in hyperthermia induced brain pathology is not investigated so far. Our previous [...]