antibodies – TechConnect Briefs

The biodegradable polymeric PLA-PEG nanoparticles is an efficient delivery system for a chlamydial M278 mucosal nanovaccine that provides protective systemic and mucosal antibody responses in mice

Verma R., Sahu R., Dixit S., Singh S.R., Dennis V.A., Alabama State University, US

The rising concerns relating to the failure of public health programs, relying mostly on antibiotic treatments to control the plethora of disease manifestations caused by Chlamydia trachomatis in humans, strongly begs the urgency for an [...]

The development of multicolor panels with Quantum Dots-conjugated antibodies for diagnostics of Chronic Lymphoid Leukemia (CLL) by conventional flow cytometer

Barteneva N., Vorobjev I., Harvard Medical School, US

Diagnostics of leukemia and lymphomas by flow cytometry emerged in 90-th years of last century when several consensus panels had been introduced and based on three-four color cytometry. The standard flow diagnostics approach requires 10-15 [...]

Multifunctional Bio-Nano Patterns Derived from Colloidal Self-Assembly as Model Surfaces to Study Antigen-Antibody Interactions

Krishnamoorthy S., Wright J.P., Worsfold O., Fujii T., Himmelhaus M., Fujirebio Inc., JP

Nanosphere lithography (NSL) has become a popular tool as a patterning technique recently because the method is cheap and involves extremely simple procedures compared with other nanopatterning techniques. NSL can also be applied to a [...]

Nanoconjugates of poly(malic acid) with functional modules for drug delivery

Ljubimova J.Y., Fujita M., Lee B-S, Khazenzon N.M., Wachsmann-Hogiu S., Farkas D.L., Black K.L., Holler E., Cedars-Sinai Medical Center, US

Nanoconjugates of β-poly(L-malic acid) (PMLA) have been synthesized with modules active in drug delivery, drug release, blocking of tumor-affiliated mRNA by antisense oligonucleotides, penetration of blood and cellular barriers, tissue targeting, membrane permeation, fluorescence, and [...]

Development of Tumor Targeting Magnetic Nanoparticles for Cancer Therapy

Ivkov R., DeNardo G.L., DeNardo S.J., Miers L.A., Natarajan A., Foreman A.R., Gruettner C., Adamson G.N., DeNardo G.L., DeNardo S.J., Triton BioSystems, Inc., US

111In-ChL6 MAb-linked iron oxide nanoparticles (bioprobes) pharmacokinetics, tumor uptake and the therapeutic effect of inductively heating these bioprobes by an externally applied AMF were studied in athymic mice bearing human breast cancer HBT3477 xenografts. Bioprobe [...]

Electronic Sensing of Antibodies using Carbon Nanotube Devices

Teker K., Sivakumar K., Wickstrom E., Panchapakesan B., University of Delaware, US

Carbon nanotubes (CNTs) are remarkable solid state nanomaterials due to their unique properties such as high surface area, hollow cavities, and excellent mechanical and electrical properties. Interfacing carbon nanotubes with biological materials could enable significant [...]