Sundaram S. – TechConnect Briefs

Numerical Analysis of Nanofluidic Sample Preconcentration in Hydrodynamic Flow

Wang Y., Pant K., Diffey W., Chen Z., Sundaram S., CFD Research Corporation, US

This paper presents the first, high-fidelity numerical study of nanofluidic streaming potential-based sample preconcentration. Parametric analysis is performed to capture the critical effects of pressure and background electrolyte (BGE) concentration on preconcentrator performance. Our studies [...]

Multi-physics Simulational Analysis of a Novel PCR Micro-Device

Wang Y., Pant K., Grover J., Sundaram S., CFD Research Corporation, US

While microfluidic devices for PCR amplification have critical applications in biodefense, homeland security, forensics and diagnostics, their efficient simulation and design continue to be a challenge. An experiment-only trial-and-error approach can prove to be prohibitively [...]

A Continuous Particle/Cell Sorter Using Dielectrophoresis

Wang G.R., Feng J.J., Vasantgadkar S., Pant K., Prabhakarpandian B., Krishnamoorthy S., Sundaram S., CFD Research Corporation, US

We present a novel design of a continuous microfluidic sorter for separation of cells or particles by the intelligent use of conventional negative dielectrophoresis with separation efficiency of greater than 95%. A high fidelity modeling [...]

Mixed-Methodology-Based System-Level Simulation of Biochemical Assays in Integrated Microfluidic Systems

Wang Y., Bedekar A.S., Krishnamoorthy S., Siddhaye S.S., Sundaram S., CFD Research Corporation, US

While lab-on-a-chip (LoC) systems are increasingly used in the areas of genomics, proteomics and drug discovery, their efficient simulation and design at system-level continue to be a challenge. Experimental trial-and-error and multiphysics-based high fidelity computation [...]

Simulation of Electrokinetic Flow and Analyte Transport in Nano Channels

Feng J.J., Krishnamoorthy S., Wang G.W., Sundaram S., CFD Research Corporation, US

This paper demonstrates the electrokinetic flow and transport of charged and neutral analytes in nanochannels by solving full system of governing Poisson-Nernst-Planck equations without any assumptions. The issues related to the spatial and time scales [...]

Computational Proof-of-Concept of Next-Generation Nucleotide–Tunneling-Current-Based Nanopore Sequencing Devices

Sengupta D., Jenkins J., Sikorski Z., Sundaram S., CFD Research Corporation, US

A complete knowledge of the DNA sequence of an individual can yield fundamental insight into disease diagnosis, treatment and possibly prevention. To date the most reliable method of determining a genetic sequence is through the [...]

Multi-scale, Mechano-biological Model of Nanoparticle Toxicity

Jenkins J., Pant K., Hood J., Sundaram S., CFD Research Corporation, US

Multiscale simulation of the toxic physiological effects of short and long term exposure to nanoparticles (NP) requires a unified quantitative understanding of NP deposition, partitioning of NP within the body (lung, liver, spleen, and brain), [...]

A Computational Model for the Design of ElectroWetting On Dielectric (EWOD) Systems

Bedekar A.S., Jenkins J.W., Sundaram S., CFD Research Corporation, US

Microfluidics has enabled the development of integrated lab-on-a-chip (LoC) devices for use in a clinical diagnostics, high throughput screening, drug discovery, biodefense and environmental monitoring. Although most microfluidic devices are based on continuous flow of [...]

Characterization of a Solid State DNA Nanopore Sequencer using Multi-Scale (Nano-to-Device) Modeling

Jenkins J.W., Sengupta D., Sundaram S., CFD Research Corporation, US

The rapid convergence of nanotechnology and biotechnology has generated a need for design tools that can incorporate sufficiently detailed models of the nanoscale molecular phenomena with overarching transport and related effects in microfluidic devices. Currently, [...]

A Multi-scale, Integrative Model of Cellular Electrophysiological Response Incorporating Intra/Extra-cellular Transport & Dynamics

Feng J.J., Krishnamoorthy S., Sundaram S., CFD Research Corporation, US

Spurred by the growing confluence of nano and bio technologies, several novel micro/nano platforms (see for example, whole cell patch clamp devices [1]) are emerging for the high-throughput and/or high-fidelity study of the electrophysiological response [...]