Jenkins J. – TechConnect Briefs

Establishing a GMP manufacturing site for nanoparticles

Sepulveda C.A., Roth J.A., Lu C., Ji L., Ramesh R., O’Connor S., Sadeghi T., Flagge F., Baez O., Shen A.C., Mondesir E., Jenkins J., Shpall E., McMannis J.D., University Texas MD Anderson Cancer Center, US

An active clinical trial at MD Anderson Cancer Center uses DOTAP:Chol liposomes as a non-viral vector for gene therapy. This therapeutic product needs to be produced fresh for each administration. Originally, the manufacture of the [...]

Computational Proof-of-Concept of Next-Generation Nucleotide–Tunneling-Current-Based Nanopore Sequencing Devices

Sengupta D., Jenkins J., Sikorski Z., Sundaram S., CFD Research Corporation, US

A complete knowledge of the DNA sequence of an individual can yield fundamental insight into disease diagnosis, treatment and possibly prevention. To date the most reliable method of determining a genetic sequence is through the [...]

Multi-scale, Mechano-biological Model of Nanoparticle Toxicity

Jenkins J., Pant K., Hood J., Sundaram S., CFD Research Corporation, US

Multiscale simulation of the toxic physiological effects of short and long term exposure to nanoparticles (NP) requires a unified quantitative understanding of NP deposition, partitioning of NP within the body (lung, liver, spleen, and brain), [...]

Multiscale (Nano-to-Micro) Design of Integrated Nanobio Systems

Jenkins J., Hagan M., Chakraborty A., Sundaram S., CFD Research Corporation, US

Biological systems have the first level of organization at the nanoscale. Proteins, DNA, RNA, ion channels are nanoscale systems that leverage molecular interactions to perform specific tasks. Integrated nano-bio systems have emerged as strong candidates [...]