TiO2 Nanowired Cerebrolysin reduces neuron-specific ubiquitin carboxyl-terminal esterase-L1 (UCHL1) in Alzheimer’s Disease and brain pathology

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Our military personnel during combat operations are vulnerable to various kinds of traumatic brain injuries. These soldiers are prone to develop neurodegenerative diseases e.g., Alzheimer’s Disease (AD) over time. Thus, efforts should be made to [...]

Nanodelivery of Cerebrolsyin in combination with neprilysin induces neuroprotection in Alzheimer’s Disease pathology following brain injury

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Neprilysin (NPL) is an endogenous enzyme that functions as rate-limiting step in amyloid-beta peptide (AβP) degradation. There are reasons to believe that an imbalance between production and clearance of AβP results in its accumulation leading [...]

TiO2 Nanowired Cerebrolysin enhances neuroprotective effects of mesenchymal stem cells following concussive head injury at hot environments

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Concussive head injury (CHI) could lead to either instant death or lifetime disabilities. Our soldiers are highly vulnerable to CHI during combat operations. Thus, to treat these soldiers effectively novel strategies using combination therapy is [...]

Mn nanoparticles exacerbates closed head injury induced blood-brain barrier disruption, brain pathology, and sensory motor dysfunctions. Neuroproetction by Nanowired delivery of 5-HT2 receptor antagonists Ketanserin and Ritanserin

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This innovation deals with adverse effects of Mn nanoparticles on brain pathology in concussive head injury. Also Mn nanoparticles treatment alters therapeutic modalities. The novel data presented in the abstract show that Mn exposure to [...]

TiO2 nanowired delivery of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) induces profound neuroprotection in concussive head injury

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To develop suitable therapeutic strategies for concussive brain injury (CHI), we have explored the role of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) in a rat model. We delivered this compound alone and also using Titanium [...]

Nanodelivery of Cerebrolysin Induces Profound Neuroprotection in Heat Stroke Following Chronic Hypertension in Combination with SiO2 and Carbon Nanoparticles Induced Exacerbation of Brain Damage

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Our military personals are often exposed to combat stress induced hypertension in an environment rich in various nanoparticles emanating from different sources e.g., gun powder explosion or blast injuries. Furthermore, combat or peacekeeping activity in [...]