Liepmann D. – TechConnect Briefs

A Computational Model with Experimental Validation for DNA Flow in Microchannels

Nonaka A., Gulati S., Trebotich D., Miller G.H., Muller S., Liepmann D., UC Davis / Lawrence Livermore National Laboratory, US

We compare a computational model to experimental data for DNA-laden flow in microchannels. The purpose of this work in progress is to validate a new numerical algorithm for viscoelastic flow of an Oldroyd-B fluid. Significant [...]

A Numerical Algorithm for Complex Biological Flow in Irregular Microdevice Geometries

Trebotich D., Colella P., Miller G.H., Nonaka A., Marshall T., Gulati S., Liepmann D., Lawrence Livermore National Laboratory, US

We present a numerical algorithm to simulate non-Newtonian flow in complex microdevice components. The model consists of continuum viscoelastic incompressible flow in irregular microscale geometries. Our numerical approach is the projection method of Bell, Colella [...]

A Numerical Model of Viscoelastic Flows in Microchannels

Trebotich D., Colella P., Miller G., Liepmann D., Lawrence Livermore National Laboratory, US

We present a numerical method to model non-Newtonian, viscoelastic flow at the microscale. The equations of motion are the incompressible Navier-Stokes equations coupled with the Oldroyd-B constitutive equation. This constitutive equation is chosen to model [...]

Complex Fluid Dynamics in BioMEMS Devices: Modeling of Microfabricated Microneedles

Liepmann D., University of California-Berkeley, US

MEMS technologies promises to revolutionize health care by providing precise control of biological fluids for both diagnoses and treatments. For example, microneedles can be used for sample collection for biological analysis, delivery of cell or [...]

Complex Fluid Dynamics in BioMEMS Devices

Liepmann D., University of California-Berkeley, US

MEMS technologies promises to revolutionize health care by providing precise control of biological fluids for both diagnoses and treatments. For example, microneedles can be used for sample collection for biological analysis, delivery of cell or [...]

Optimization of a MEMS Based Micro Capillary Pumped Loop for Chip-Level Temperature Control

Trebotich D., Kirshberg J., Teng J., Liepmann D., University of California, US

Recent results in the microfluidics group at the Berkeley Sensor and Actuator Center and the Air Force Research Laboratory have shown that a micro-capillary pumped loop (micro-CPL) can move extreme amounts of heat (< 200 [...]

Computational Design Analysis for In-Plane Microfluidic Valves

Dickey C.K., Makhijani V.B., Deshmukh A., Liepmann D., CFD Research Corporation, US

Simulations of fluid flow across in-plane microvalves were performed using an advanced multi-physics commercial software system and compared with experimental data. Model validation required careful consideration of leakage pathways left by fabrication artifacts. Following model [...]

Modeling of Blood Flow in Simple Microchannels

Trebotich D., Chang W., Liepmann D., University of California-Berkeley, US

Optimal design of medical micro-assay systems will require computational modeling capabilities. Most existing models are based on macroscale experiments with smallest length dimensions comparable to that of a capillary due to the fact that the [...]

Characterization of DNA Flow through Microchannels

Shrewsbury P.J., Muller S.J., Liepmann D., University of California-Berkeley, US

Advances in silicon fabrication technology enable the reproduction of laboratory apparatus, and theoretically biochemical processes, on a microscale. The implementation of this technology, however, necessitates additional study as fluid dynamics change at this scale and, [...]