Lai J.C.K. – Page 3 – TechConnect Briefs

Surfactant Effect on Intercellular Transport of DNA, Proteins, and Electrolytes

Assan D., Gao X., Lai J.C.K., Leung S.W., Idaho State U, US

Surfactants play a key role on bodily functions at molecular level, such as cell signaling and signal transmission. Their importance in cell survival is well recognized, but the surfactant effect on intermolecular/interfacial mass transport is [...]

Comparison of Anchoring Materials for High Performance Sensors Modified with Nanoparticles and Enzymes

Gao X., Assan D., Lai J.C.K., Leung S.W., Idaho State University, US

We have previously developed some of the most sensitive biosensors/electrodes modified by Au nanoparticles and enzymes that are capable of detecting concentration levels below ppb. These sensors were fabricated with composite layers of nanomaterials and [...]

Advanced Biofuel Cell Composed of Highly Modified Electrodes for Biomedical Applications

Leung S.W., Lai J.C.K., Idaho State University, US

A biofuel cell comprised an anode and cathode modified with highly branched polymers, nano Au sol-gel, and reaction specified bioenzymes was constructed. In this study, lactate dehydrogenase (LDH) and glutamate dehydrogenase (GDH) were the enzymes [...]

Advanced Biofuel Cell Composed of Highly Modified Electrodes for Biomedical Applications

Leung S.W., Lai J.C.K., Idaho State University, US

A biofuel cell comprised an anode and cathode modified with highly branched polymers, nano Au sol-gel, and reaction specified bioenzymes was constructed. In this study, lactate dehydrogenase (LDH) and glutamate dehydrogenase (GDH) were the enzymes [...]

Molecular Effects of Silicon Dioxide Nanoparticles on Cell Survival Signaling of Dorsal Root Ganglion (DRG) Neurons and Schwann Cells

Jain A., Jaiswal A.R., Lu S., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

The molecular mechanisms underlying the pathophysiology of peripheral neuropathies have not been fully elucidated. To meet the need for suitable cell culture models in vitro of peripheral nervous system (PNS) neural cells that allow long-term [...]

Effects of Silicon Dioxide Nanoparticles on Peripheral Nervous System Neural Cell Models

Jaiswal A.R., Lu S., Pfau J., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Cell model systems in vitro facilitate the high through-put screening of putative toxicity of a variety of nanomaterials, including nanoparticles. However, most of such cell models consisted of non-neural cells. We have developed several central [...]

Differential Cytotoxic Effects of Titanium Oxide Nanoparticles on Peripheral Nervous System Neural Cells

Lu S., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University College of Pharmacy, US

The health impact of exposure to TiO2 nanoparticles is poorly documented although exposure to the particles is known to elicit inflammatory responses in lung tissue. We recently found treatment with TiO2 micro- or nanoparticles induce [...]

New in Vitro Strategy of Astrocytoma (Astrocytes-like) Cells Treated with Pioglitazone ( PPAR gamma agoinst) Offers Neuroprotection Against Nanoparticle-Induced Cytotoxity

Wong Y.Y.W., Jaiswal A., Dukhande V.V., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Recently, we and others have developed several cell models for the investigation of the molecular mechanisms underlying the cytotoxicity of nanoparticles of several metallic and non-metallic oxides. These important findings have raised the awareness for [...]

Effects of Chitosan and Nanoparticles on Survival of Schwann Cells and Dorsal Root Ganglion Neurons

Lai J.C.K., Gao W., Leung S.W., Idaho State University, US

We have systematically examined the effects of chitosan film or chitosan in combination with nanometal particles (nanogold or nanosilver particles) on the growth of Schwann cells (S16) and DRG neurons (50 B 11). Results of [...]

Elucidation of Neuroprotective Properties of Astrocytoma (Astrocytes-like) Cells in Neural Cell Culture Models In Vitro: Applications in Tissue Engineering and Nanotoxicology

Wong Y.Y.W., Jaiswal A., Dukhande V.V., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Evidence is accumulating that cell culture models in vitro facilitate high throughput and mechanistic studies in tissue engineering. We have developed several cell models for the systematic investigation of molecular mechanisms underlying the putative cytotoxicity [...]