Elucidation of Neuroprotective Properties of Astrocytoma (Astrocytes-like) Cells in Neural Cell Culture Models In Vitro: Applications in Tissue Engineering and Nanotoxicology

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Evidence is accumulating that cell culture models in vitro facilitate high throughput and mechanistic studies in tissue engineering. We have developed several cell models for the systematic investigation of molecular mechanisms underlying the putative cytotoxicity of nanoparticles and other nanomaterials. Our previous findings led us to hypothesize that different stress factors can elicit and/or enhance the neuroprotective effects of astrocytes through the activation of astrocytic signaling and alteration of astroglial function; we have initiated a series of studies employing our cell models. The results of our ongoing studies demonstrate that U-87 (astrocytes-like) astrocytoma cells prevent SK-N-SH (neurons-like) neuroblastoma cells against pathophysiological assaults (e.g., oxidative stress) under several sets of culture conditions not previously studied. Thus, our results may have pathophysiological implications in neuroprotection but also implications and applications in tissue engineering and nanotoxicological research. (134 words)

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Journal: TechConnect Briefs
Volume: 3, Nanotechnology 2010: Bio Sensors, Instruments, Medical, Environment and Energy
Published: June 21, 2010
Pages: 561 - 564
Industry sectors: Advanced Materials & Manufacturing | Medical & Biotech
Topics: Environmental Health & Safety of Nanomaterials
ISBN: 978-1-4398-3415-2