Lai J.C.K. – Page 2 – TechConnect Briefs

Cytotoxic Effects of Silver and Gold Nanoparticles in Human Glioblastoma U87 Cells

Gao W., Leung S.W., Bhushan A., Lai J.C.K., Idaho State University College of Pharmacy, US

Nanoparticles have contributed significantly to the design of new drug delivery and targeting in cancer chemotherapy. Consequently, some of the desirable qualities of silver and gold nanoparticles have prompted their novel applications in cancer nanobiotechnology. [...]

Detection of Prostate-Specific Antigen (PSA) with an Ultra High Performance Electrode Modified with Sol-Gel Au Nanoparticles

Leung S.W., Mozneb S., Lai J.C.K., Assan D., Idaho State University, US

Prostate cancer is one of the leading cancer causing death in men, especially in western developed countries. Prostate-specific antigen (PSA) is one of the biomarker that can be used to diagnose prostate cancer, although using [...]

A New Biocomposite Electrode Sensor for the Detection of Oxidative Reactions

Assan D., Gao X., Lai J.C.K., Leung S.W., Idaho State University, US

Hemoglobin has a very strong affinity with oxygen and thus is a good catalyst to carry oxygen for many oxidation reactions. Many researchers have explored this property of hemoglobin to develop sensors for the detection [...]

Entry of Short Multi-Wall Carbon Nanotubes into Dorsal Root Ganglion (DRG) Neurons Induces Cell Death

Lai J.C.K., Gao W., Bhushan A., Bearden S.E., McDougall L., Leung S.W., Idaho State University College of Pharmacy, US

Carbon nanotubes (CNTs) have found their way into diverse industrial and biomedical applications because of their unique physico-chemical properties. However, the human health impact of exposure to CNTs is unknown. Our recent and ongoing studies [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells

Tadinada S.M., Lai J.C.K., Lai M.B., Idikuda V.K., Mukka K., Singh M.R.M., Pfau J., Bhushan A., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy, US

Targeted drug delivery systems with minimal potential adverse/side effects are gaining utility in diverse applications. Uses of nanomaterials to design such targeted drug delivery are escalating exponentially. Nevertheless, the biocompatibility of nanomaterials is inadequately addressed. [...]

Performance Comparison of Immunosensors Modified with Polymers, Nanoparticles and Antibody

Leung S.W., Lai J.C.K., Assan D., Idaho State University, US

Our research group is in the quest of developing a biosensor platform that is fast in response time, versatile that can be used to detect a variety of chemicals species and metabolites, and ultra-sensitive that [...]

Ultra-High Performance Immunosensor Prepared by Glassy Carbon Electrode Modified with Nano Gold Particles and Antibody

Assan D., Mozneb M., Lai J.C.K., Leung S.W., Idaho State University, US

In previous reports, we have successfully fabricated biosensors that could measure chemical species that are important in environmental monitoring, as well as metabolites that are indicators of the proper functioning of our body. In our [...]

Cytotoxic Effects of Four Metallic Oxide Nanoparticles on Dorsal Root Ganglion (DRG) Neurons

Lu S., Bhushan A., Leung S.W., Daniels C.K., Lai J.C.K., Idaho State University, US

Metallic oxide nanoparticles have diverse industrial applications because of their exploitable physico-chemical and other properties. Consequently, the occupational environmental exposure of humans to these nanparticles is increasing; however, the health impact of their exposure has [...]

Cytotoxicity of Magnesium Oxide Nanoparticles in Schwann Cells

Idikuda V.K., Jaiswal A.R., Wong Y.Y.W., Bhushan A., Leung S.W., Lai J.C.K., Idaho State University, US

Diverse applications of metal oxide nanoparticles in various industries have been accelerating in the last decade. Magnesium oxide (MgO) nanoparticles have been employed in ceramics, and as adhesive and additive in chemical raw materials, leading [...]

Cytotoxic Effects of Short Multi-Wall Carbon Nanotubes in Dorsal Root Ganglion (DRG) Neurons

Lai J.C.K., Gao W., Bhushan A., Leung S.W., Idaho State University College of Pharmacy, US

Because of their unique physico-chemical properties, carbon nanotubes (CNTs) have found their way into diverse industrial and biomedical applications. Their escalating uses in multiple industries result in enhanced occupational human exposure to CNTs. However, the [...]