Lafuente J.V. – Page 2 – TechConnect Briefs

TiO2 Nanowired Cerebrolysin reduces neuron-specific ubiquitin carboxyl-terminal esterase-L1 (UCHL1) in Alzheimer’s Disease and brain pathology

Muresanu D.F., Sharma A., Sharma H.S., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., University of Medicine & Pharmacy, RO

Our military personnel during combat operations are vulnerable to various kinds of traumatic brain injuries. These soldiers are prone to develop neurodegenerative diseases e.g., Alzheimer’s Disease (AD) over time. Thus, efforts should be made to [...]

Nanodelivery of Cerebrolsyin in combination with neprilysin induces neuroprotection in Alzheimer’s Disease pathology following brain injury

Sharma A., Sharma H.S., Muresanu D.F., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Neprilysin (NPL) is an endogenous enzyme that functions as rate-limiting step in amyloid-beta peptide (AβP) degradation. There are reasons to believe that an imbalance between production and clearance of AβP results in its accumulation leading [...]

TiO2 Nanowired Cerebrolysin enhances neuroprotective effects of mesenchymal stem cells following concussive head injury at hot environments

Sharma A., Sharma H.S., Muresanu D.F., Feng L., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Concussive head injury (CHI) could lead to either instant death or lifetime disabilities. Our soldiers are highly vulnerable to CHI during combat operations. Thus, to treat these soldiers effectively novel strategies using combination therapy is [...]

Mn nanoparticles exacerbates closed head injury induced blood-brain barrier disruption, brain pathology, and sensory motor dysfunctions. Neuroproetction by Nanowired delivery of 5-HT2 receptor antagonists Ketanserin and Ritanserin

Sharma A., Sharma H.S., Feng L., Muresanu D.F., Lafuente J.V., Tian Z.R., Ozkizilcik A., Smith M.A., Sharma A., Sharma H.S., Uppsala University, SE

This innovation deals with adverse effects of Mn nanoparticles on brain pathology in concussive head injury. Also Mn nanoparticles treatment alters therapeutic modalities. The novel data presented in the abstract show that Mn exposure to [...]

Nanowired Mesenchymal Stem cells ameliorate brain pathology exacerbated by diabetes in hyperthermia

Sharma A., Sharma H.S., Feng L., Lafuente J.V., Muresanu D.F., Tian Z.R., Patnaik R., Sharma A., Sharma H.S., Uppsala University, SE

Stem cell transplantation or injection is associated with neuroprotection in stroke and in central nervous system (CNS) injury. However, role of stem cells in hyperthermia induced brain pathology is not investigated so far. Our previous [...]