The Physics of Pressure Powered Micro-Flow Focusing Device for the Encapsulation of Live Cells

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Flow focusing devices (FFD) have emerged as a powerful tool for cell encapsulation and formation of micro-emulsions [1,2]. In the frame of live cell encapsulation, a micro-FFD using alginate solutions for the capsule and powered by highly controllable pressure pumps has been developed [3,4]. This work deals with the different aspects of the problem: the rheology of alginates, the flow regimes and flow charts, the influence of the different parameters and a scaling analysis. Experimental observations of capsules produced in the microsystem are finally shown.

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Journal: TechConnect Briefs
Volume: 2, Nanotechnology 2011: Electronics, Devices, Fabrication, MEMS, Fluidics and Computational
Published: June 13, 2011
Pages: 458 - 461
Industry sectors: Advanced Materials & Manufacturing | Sensors, MEMS, Electronics
Topics: Micro & Bio Fluidics, Lab-on-Chip
ISBN: 978-1-4398-7139-3