US – Page 453 – TechConnect Briefs

Modeling of Blood Flow in Simple Microchannels

Trebotich D., Chang W., Liepmann D., University of California-Berkeley, US

Optimal design of medical micro-assay systems will require computational modeling capabilities. Most existing models are based on macroscale experiments with smallest length dimensions comparable to that of a capillary due to the fact that the [...]

Electrodynamic Transport, Electroporation and Lysis of Cells in Pharmacological and Bioanalytical Microsystems

Przekwas A.J., Chen Z.J., Athavale M., CFD Research Corporation, US

Biological information is stored in cells and is the prime object of interest of pharmacological, biomedical, and bioanalytical professionals. Whatever the interest: elcectroporative drug delivery and pharmacodynamics, in vivo PCR, infection pathology, DN

Inverted Method for Simulation of Electrokinetic Transport in Microchannel Devices

Nilson R.H., Griffiths S.K., Sandia National Laboratories, US

An inverted method of solution is used to numerically solve the equations governing electrokinetic fluid flow and species transport in microscale turns, junctions and curved channels. Rather than solving for the electric potential and fluid [...]

Analysis of Sample Transport in Capillary Electrophoresis Microchip Using Full-Scale Numerical Analysis

Krishnamoorthy S., Feng J.J., Makhijani V.B., CFD Research Corporation, US

An implicit finite-volume numerical scheme has been developed to solve the three-dimensional transport equations along with fully-coupled ionization equilibria in acid/base systems. The scheme solves conservation equations for mass and momentum while satisfying the electroneutrality [...]

Mixed-Dimensionality, Multi-Physics Simulation Tools for Design Analysis of Microfluidic Devices and Integrated Systems

Przekwas A.J., Makhijani V.B., CFD Research Corporation, US

Computational design of microfluidic devices and integrated microsystems involves several strongly coupled physical disciplines, including fluid mechanics, heat transfer, stress/deformation dynam-ics, electrokinetics, biochemistry and others. CFDRC is dev

Surface Tension Induced Instability of Viscous Liquid Jets

Furlani E.P., Delametter C.N., Chwalek J.M., Trauernicht D., Eastman Kodak Company, US

Viscous liquid jets are inherently unstable, and drop formation can be induced by various means including surface tension modulation. Furthermore, surface tension is temperature dependent, and can be modulated by locally heating the surface of [...]

Reconfigurable Microfluidic System Architecture Based on Two-Dimensional Electrowetting Arrays

Ding J., Chakrabarty K., Fair R.B., Duke University, US

We present an architectural design and optimization methodology for performing biochemical reactions using two-dimensional electrowetting arrays. We define a set of basic microfluidic operations and leverage electronic design automation principles for system partitioning, resource allocation, [...]

A Combined DSMC/Meshless Technique for Multiscale Analysis of Microfluidic Filters

Aktas O., Aluru N.R., University of Illinois at Urbana-Champaign, US

A multiscale method that couples a meshless Stokes solver and a DSMC simulator is reported. The method is based on overlapped Schwarz alternating method with Dirichlet-Dirichlet type boundary conditions for domain decomposition and meshless interpolation

A Method for Determining the Dependence of Integrated Circuit Performance on Silicon Process, Device and Circuit Parameters

Sipahi L.B., Myers B.A., Sanders T.J., Intersil Corporation, US

The goal of this project is to develop a structured methodology for achieving a design of a block of circuit in an IC which is more compliant to the specification using a multiple simulation approach. [...]

Statistical Optimal Design of Microelectromechanical Systems (MEMS)

Ren H., Jog A., Fair R.B., Duke University, US

A three-step technique for MEMS quality optimization is demonstrated. It exploits the relative merits of its constituent optimization components. Analog Devices' ADXL50 accelerometer was the test device with microstructure dimen-sions serving as design parameters. Manufacturing [...]