US – Page 399 – TechConnect Briefs

DEP Particle Dynamics and the Steady Drag Assumption

Wereley S.T., Whitacre I., Bashir R., Li H.B., Purdue University, US

The interaction of fluid drag, dielectrophoretic forces, and Brownian motion on a nanoparticle's motion is studied using a microfluidic chip with interdigitated electrodes. The flow domain is a 12 micron deep by 150 micron wide [...]

Optimization of Mixing in an Active Micromixing Device

Mathew G., Mezic I., Serban R., Petzold L., university of california, santa barbara, US

Microscale mixers can be divided into two broad classifications - passive and active. Passive mixers rely on geometric properties of the channel shape whereas active mixers rely on time-dependent perturbation of the fluid flow to [...]

SOI Processing of a Ring Electrokinetic Chaotic Micromixer

Zhang Y.T., Chen H., Mezic I., Meinhart C.D., Petzold L., MacDonald N.C., university of california, santa barbara, US

Micromixing has been an active research area in the past decade due to the rapid expanding application of the lab-on-a-chip system in life science. Using the silicon bulk micromachining technology, a ring electroosmotic micromixer, which [...]

Flow Simulation of a Microfluidic Analog of the Four-Roll Mill

Phelan_Jr. F.R., Hudson S.D., NIST, US

The fluid dynamics of geometries for liquid state materials characterization in microfluidic devices are investigated. A pressure driven device using microchannels is sought that has an adjustable flow type, approximating the function of the four-roll [...]

Analysis of Blood Extraction from a Lancet Puncture

Kuriger R.J., Romanowicz B.F., CFD Research Corporation, US

A computational model was created utilizing the CFD-ACE+ software to model blood flow from a lancet puncture of the skin. A two-dimensional axisymmetric model was developed and the skin tissue was modeled as a porous [...]

In-Plane Micropump: Design Optimization

Sin J., Lee W.H., Stephanou H.E., RPI, US

This paper presents the fabrication, analysis and optimization of a novel monolithically fabricated diaphragm micropump, referred to as an in-plane micropump. Compared to previous technology, the micropump in this paper is fabricated to have all [...]

Liquid Disintegration: Investigation of Physics by Simulation

Zeng J., Korsmeyer T., Coventor, Inc., US

Liquid disintegration includes the processes of formation of droplets and droplet fission. It is important in inkjet printing and in the miniaturization of biochemical analytical devices. This paper reports on an investigation of the mechanism [...]

Nano-structure and Phase Transitions in the Liquid Phase of Metallic and Non-metallic Elements

Vezzoli G.C., Institute for the Basic Sciences, US

The generally accepted version of the structure of the liquid phase is that of a single "homogeneous" phase, with a structure which is more or less homogeneous throughout the pressure-Temperature (p-T) field in which it [...]

Bio-Impedance Sensing Device (BISD) for Detection of Human CD4+ Cells

Mishra N.N., Retterrer S., Zieziulewicz T.J., Isaacson M., Szarowski D., Mousseau D.E., Lawrence D.A., Turner J.N., New York City Department of Health, US

The aim of this work is to develop a small on-chip bio-impedance sensing device (BISD) to rapidly detect and quantify cells with a specific phenotype in a heterogenous population of cells (e.g., human CD4+ cells [...]

Micro-Patterning of Ionic Reservoirs within a Double Bilayer Lipid Membrane to Fabricate a 2D Array of Ion-Channel Switch Based Electrochemical Biosensors

Sansiñena J.M., Yee C.K., Sapuri A., Swanson B.I., Redondo A., Parikh A.N., Los Alamos National Laboratory, US

We present a simple approach for the design of ionic reservoir arrays within a double phospholipid bilayer to ultimately develop a 2D array of ion-channel switch based electrochemical biosensors. As a first step, a primary [...]