US – Page 339 – TechConnect Briefs

Molecular Dynamics Simulation of a Single Stranded (ss) DNA

Chatterjee S., Gersten B., Thakur S., Burin A., Queens College, CUNY, US

The objective of this study was to develop an understanding of the essential physical properties of short-single stranded DNA (ssDNA) towards the development of new DNA based biosensors. To achieve this goal, various thermodynamic properties [...]

Modeling of Cellular Communication

Barjis I., Barjis J., Samarrai W., Augustin I., Barjis I., Barjis J., New York City College of Technology, US

This paper introduces application of Rule based to molecular biology. In particular, it illustrates how by means of rule based the process of cellular communication can be modeled, and analyzed, where the model could be [...]

Reflex-arc on a chip: An in silico cell culture analogue

Wilson K.A., Das M., Molnar P., Hickman J.J., University of Central Florida, US

To overcome the shortcomings of in vitro and animal models we are developing a microscopic cell culture analogue (microCCA) of the spinal reflex-arc. The present work draws on advances in a wide variety of technical [...]

Ligand-dependent changes in the SPR of magnetic nanoparticles

Radu L., Caruntu D., White M., Wiley J., Hanson P., University of New Orleans, US

Currently, there is an increasing interest in using magnetite nanoparticles in biological and medical applications. The interest is driven by a combination of their biocompatibility, chemical stability and magnetic properties. Magnetite nanoparticles with diameter 10 [...]

A Sensitive Peptide-Nanotube Based Pathogen Assay

MacCuspie R.I., Banerjee I.A., Gummalla S., Mostowski H., Krause P., Matsui H., Hunter College, US

A novel peptide nanotube-based multiplexed pathogen assay has been developed that has high sensitivity, detecting as few as 100 pathogens per mL in as little as 0.5mL. Multifunctional nanotubes detect viruses by selectively binding antibody [...]

Biosensors Fabricated through Electrostatic Assembly of Enzymes/Polyelectrolyte Hybrid Layers on Carbon Nanotubes

Lin Y., Liu G., Wang J., Pacific Northwest National laboratory, US

Carbon nanotubes (CNTs) have emerged as a new class of nanomaterials that is receiving considerable interest because of their unique structure and mechanical and electronic properties. One promising application of CNTs involves their use in [...]

Carbon Microstructures for Glucose Biosensor

Xu H., Malladi K., Wang C., Madou M.J., University of California Irvine, US

In this work we report on a novel design and fabrication of glucose sensor based on carbon post electrode array. Apart from the fact that carbon has a wide electrochemical stability window, one advantage of [...]

Assembly of DNA Rotaxanes for AFM Based DNA Sequencing

Spadola Q., Qamar S., Lin L., Lindsay S.M., Ashcroft B., Zhang P., Lindsay S.M., The Biodesign Institute at Arizona State University, US

The desire to sequence DNA is fueled by the knowledge that the information locked inside of genomes can help fields as varied as molecular medicine, bioarcheology, forensics, and environmental science. The challenge is to establish [...]

Development of Nanoprobes as Glucose Biosensors

Dweik M., Grant S., University of Missouri-Columbia, US

In 2005, the American Diabetes Association (ADA) reported that 20.8 million people have diabetes, making it the fifth leading cause of death by disease in the USA. The objective is to focus on the development [...]

Electrophoretically Actuated Nanoscale Optoentropic Transduction Mechanisms

Sullivan B., Dehlinger D., Zlatanovic S., Esener S., Heller M.J., University of California San Diego, US

We have identified a novel oscillatory optoentropic transduction mechanism that may enable modern communications theory to augment DNA and protein target detection within complex biological samples. More specifically, we have shown that electric field driven [...]