US – Page 270 – TechConnect Briefs

Role of Nano-chirality and broken symmetry in hostile organism penetration of host cell DNA

Vezzoli G.C., Institute for the Basic Sciences, US

We show that broken symmetry, at the nano level, of biomolecules is key to phage invasion of a host cell, and take-over of the cell’s RNA-DNA replication processes. We determined that perturbation of cellular water [...]

Studies of Hybrid Nano-Bio-System: Single-Walled Carbon Nanotubes and Hydrogenase

Svedruzic D., Blackburn J.L., McDonald T.J., Heben M.J., King P.W., National Renewable Energy Laboratory, US

We have examined changes in single-walled carbon nanotubes (SWNT) optical signals upon addition of recombinant [FeFe] hydrogenases from Clostridium acetobutylicum or Chlamydomonas reinhardtii. We found evidence that novel and stable charge-transfer complexes are formed only [...]

Investigating electrospun nanofibrous scaffold mechanical properties

Farboodmanesh S., Chen J., Pelealuw J.L., Cloutier D.E., University of Massachusetts-Lowell, US

There has been a considerable growth and development in electrospun nanofibers for research activity, as well as commercial fabrication over the past couple of decades. These continuous nanofibers are solution driven exclusively by an electric [...]

Modified AFM Probes for Nanoscale Biomolecular Recognition Studies

Johnson W.T., Agilent Technologies, US

Biomolecular interactions, which are responsible for many physiologically important processes, can be studied by molecular recognition force microscopy (MRFM). In MRFM, nanoNewton scale single molecule interactions are observed and quantified one by one as an [...]

Proton Uptake by Dormant Bacterial Spores

Kazakov S.V., Pace University, US

A dormant bacterial spore is regarded as a natural ionic reservoir, i.e. a system capable of changing the external pH or ionic strength by accumulating or releasing ions. In this work, we introduce a method [...]

Enrichment of serum phosphopeptide by nanoparticles to identify cancer biomarker

Shah A., Sachdev V., Bharti A., Boston University Medical School, US

The role of kinases in transformation and cancer progression is established. We hypothesize that The role the specific phosphoproteins/phosphopeptides will be present in cancer patient serum as leak proteins and their isolation and identification will [...]

Gold Nanoparticle Bioconjugates for Biomolecular Imaging and Detection

Liu X., Dai Q., Coutts J., Austin L., Knowles G., Huo Q., University of Central Florida, US

Gold nanoparticles and colloids have been used for a long time in biomolecular imaging and detection. With further understanding on many of the electrical and optical properties of gold nanoparticles revealed recently, the application of [...]

Local temperature measurement near remotely heated,ultra-small gold nanoparticles

Gupta A., Denver H., Borca-Tasciuc D-A., Joshi A., Kane R., Hella M., Rensselaer Polytechnic Institute, US

This work presents a novel technique to measure the temperature in the vicinity (~3.5 nm) of a remotely heated, ultra-small gold nanoparticle. The temperature measurement is carried out employing fluorescent thermometry and core/shell CdSe quantum [...]

Functionalized Mesoporous Silica Nano-particle for Optical Bio-detection

Maki G., Maki W.C., Mishra N.N., Filanoski B., Rastogi S.K., Cameron E., Maki G., Maki W.C., University of Idaho, US

Mesoporous silica nano-particles were immobilized with luciferase and antibodies for immune-bioluminescence detection of Staphylocuccus aureus enterotoxin B (SEB) and C (SEC). Mesoporous silica nano-particles were used as matrix to immobilize antibodies specific for enterotoxins and [...]

Optimizing nanoparticle functionalization for quantum dot formation

Hooper J.B., Bedrov D., Smith G.D., Kim H., University of Utah, US

Utilizing state-of-the-art molecular dynamics simulation techniques, we have developed a methodology for determining the gross functionalization parameters required to promote formation of small, compact, and stable nanoparticle clusters in aqueous solutions. The ultimate goal of [...]