Nano Bio Materials and Tissues – TechConnect Briefs

Bioartifical mucosa: delivery of biomaterials to the skin-percutaneous device interface in in vitro human organotypic skin cultures

Peramo A., Marcelo C.L., Goldstein S.A., Martin D.C., University of Michigan, US

The use of medical devices passing through the skin has continued to rise. In conjunction with an increased use of catheterization and a general tendency toward minimally invasive procedures in medicine, the need for rapid [...]

Chitosan Film/Membrane as a Surface to Alter Brain Glioma Growth and Migration

Gao W.J., Wang Y.-H., Gu H.-Y., Jandhyam S., Dukhande V.V., Lai J.C.K., Lai M.B., Leung S.W., Bhushan A., Lai J.C.K., Lai M.B., Idaho State University, US

A hydrophilic polysaccharide derived from chitin, chitosan has gained increasing popularity in biomedical applications such as tissue engineering, wound dressing, and drug delivery because of its presumed biocompatibility. These applications were founded on chemical similarities [...]

Adhesion and Differentiation of Neuronal Cell on Photoresist Derived Carbon Substrates

Pampuro R., Chen L., Zou T., Zhou H., Worcester Polytechnic Institute, US

Cellular response to substrate topography and chemistry is a crucial aspect in guided neurite growth for application in neuroregenerative medicine. Experiments investigating cell culture on nanopatterned surfaces have elucidated the nuances of cell-substrate interaction. Among [...]

Antimicrobial properties of silver coated CNT

Ashour D., Subbarayan P., Adiani L., Boyoglu S., Mohammad G., Rangari V., Jeelani S., Ram Singh S., Pillai S., Alabama State University, US

Surface microbial infestation of biomedical devices such as catheters, prosthetics, and implants can result in serious infection and device failure. Surface-centered infections are also implicated in food spoilage, and spread of food-borne diseases. Hence, there [...]

Zinc Oxide Based Hydrogel for Bio-Applications

John S., Marpu S., Fujita Y., Omary M., Neogi A., University of North Texas, US

ZnO can be elected as a potential replacement for conventional dyes and toxic quantum dots in bio-medical applications owing to its low toxicity and high photo stability. The major drawback of using semiconductor nanoparticles including [...]

Advances in Bio imaging using the nanoparticulate contrast systems

Ng C., Pathak Y., Sullivan University College of Pharmacy, US

Recent developments in the contrast agents being used in Bio imaging especially the development of nanoparticulate contrasting agents has opened many new vistas in this field. Bio imaging is extensively used to characterize the particle [...]

Studies of Ferrite Based Magnetic Nanoparticle Uptake and Magnetocytolysis Effects on Model Cell Cultures

Rodríguez H.L., Barrera C., Herrera A., Ayala V., Latorre M., Rinaldi C., Torres-Lugo M., University of Puerto Rico, PR

To date, two main avenues by which nanoparticles appear to induce cell death have been proposed, magnetocytolysis and magnetic fluid hyperthermia (MFH). Little is known regarding the mechanisms of cell death and the main factors [...]

An Evaluation Criteria of Lower Respiratory Tract Infection Drug Resistant Patients in Need of Alveolar Fibroblasts: Match between Carbon Nanotube Bound Fibroblast Defense and Patient Drug Resistance: NIDHI Criteria

Sharma R., Goel N., Kwon S., Florida State University, US

We report first time a criterion of evaluating the need of choosing alveolar fibroblasts immune to lower respiratory tract infection (LRTI) in LRTI patients who display fatal drug resistance and specific pattern of bacterial infection. [...]

Effects of Crosslinking Condition on Mechanical and Biological Properties of Biomimetic Fibrous Composite Material for Arterial Medial Equivalent

Madhavan K., Belchenko D., Tan W., University of Colorado at Boulder, US

This study involves the mechanical and biological characterization of crosslinked collagen-based scaffolds for arterial medial-equivalent. These scaffolds are made from a mixture of collagen, chitosan and elastin and crosslinked with genipin. The method of optimization [...]

From Micro- to Nano- Patterning: Manipulating the Extracellular Matrix and Directing Cell Organization, Migration & Adhesion

Moten A., Harvard Univeristy/Massachusetts Institute of Technology, US

Cells are inherently sensitive to local mesoscale and microscale patterns of chemistry and topography. Recent research has investigated how surface mechanics might dictate cell behavior, affecting both cell function and differentiation. This study professes that [...]

Immobilization of Enzymes on Functionalized Magnetic Nanoparticles for Efficient Biocatalysis

Wang D.I.C., Wang W., Li Z., Wang D.I.C., Wang W., National University of Singapore, SG

In this paper, iron oxide magnetic nanoparticles were synthesized by co-precipitation method and were functionalized with aldehyde group. Spherical superparamagnetic nanoparticles with diameter of 100 nm were obtained based on the results of field emission [...]

In Vivo Real Time Raman Spectroscopy Detection of Carbon Nanotube Kinetics in Lymph, Blood and Tissues

Biris A.S., Galanzha E.I., Li Z., Mahmood M., Xu Y., Dervishi E., Zharov V.P., University of Arkansas at Little Rock, US

The development of novel therapies using unique nanostructures for molecular targeting has become a major area of biological research. Here, we present the first report of the use of carbon nanotubes (CNTs) as high contrast [...]

Surface Constructions of Nano-Micro Structured CaP Biomaterials and Their Biocompatibility

Lin C.J., Wang H., Hu R., Lai Y.K., Geng Z.W., Xiamen University, CN

In this work, we concentrated our attention to develop various methods for surface construction of of calcium phosphate (CaP) and their composite coatings, including octacalcium phosphate (OCP), hydroxyapatite (HAp), micropatterned titanium surface by using electrochemical [...]

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