We have developed a polymeric targeted nanoparticle-polypeptide conjugates that shows cell binding speficity and stealth properties. The targeted naoparticles binds and are taken up efficiently by Her2 expressing breast cancer cells. These nanoparticles represent a [...]
Colorectal cancer (CRC) is the second most common cause of cancer death in the USA. Current research is shifting the focus from chemotherapy to chemoprevention. The overall goal was to develop a low dose, novel [...]
Biologically adherent polymeric microsphere carriers have been shown to be effective in the oral delivery of proteins such as insulin and DNA plasmids. These microspheres are comprised of hydrophobic copolymers that appear to have a [...]
Using prostate cancer as a model, we report the drug release of pacitaxel and doxorubicin from aptamer-poly (D,L lactic co glycolic acid)-poly(ethylene glycol) (PLGA-PEG) nanoparticles used to target prostate-specific membrane antigen (PSMA), a well characterized [...]
We build on our recently reported work in Nano letters describing coating of nanoparticle cargoes with virus envelope proteins to show that the method works for viruses other than ecotropic murine leukemia viruses. We also [...]
Amphiphilic molecules, such as surfactants or lipids, spontaneously self-assemble in water, forming self-aggregates, such as micelles, bilayer membranes, tubes and vesicles. Amphiphilicity of biopolymers is one of the most important factors for their self-organization in [...]
The efficiency of non-viral gene delivery is dependent on 4 factors: DNA protection, DNA delivery across membranes, endosomal DNA release, and nuclear uptake. Here we report on the development of a new delivery technology based [...]
We report the enhancement of gene expression for rice -galactosidase gene (-Gal) in yeast cells assisted by metal nanomaterials. Au and Ag nanoparticles, and their nanocomposites, silica@Au and silica@Ag were prepared and characterized by UV-vis [...]
Polysorbate 80(Tween® 80)-coated poly(butyl cyanoacrylate) nanoparticles have been shown to enable the transport of doxorubicin (DOX) across the blood-brain barrier (BBB). This formulation produced a high antitumoral effect in an orthotopic model of the very [...]
Recently, it is very mortal that so many percentages of people get infected with chronic hepatitis as increasing trend and consequently leaded to the death because of a complication arises of cirrhosis and liver cancer. [...]
The stabilization of dopamine used in the treatment of Parkinsons is a pressing problem. When dopamine is applied systemically. destabilization may occur following penetration through the blood brain barrier (BBB). In order to circumvent this [...]
In this study, sol-gel titania implants used in the controlled rate of drug release of valproic acid to the temporal lobe of the brain were optimized to insure that the correct drug dose is delivered. [...]
An implantable biochip based on MEMS (Micro-Electro-Mechanical-Systems) was developed to treat hemorrhagic shock in the battlefied. We discuss the design, fabrication, and testing of the device. In addition, we describe an animal model validating the [...]
Superparamagnetic magnetite nanoparticles (MNPs) were synthesized via modified coprecipitation method and their physical properties were examined. The crystal structure of Fe3O4 nanoparticles (NPs) was confirmed by X-ray diffraction. From the dynamic laser scattering analysis, the [...]
Hydrogels are three dimensional hydrophilic crosslinked polymer networks, which capable of swelling in water. They have soft and elastic nature, which suggests similarities to natural tissues. Hydrogels are important in dentistry. For example, PerioChip is [...]
, Flagge F.
, Jenkins J.
, Ji L.
, Lu C.
, McMannis J.D.
, Mondesir E.
, O’Connor S.
, Ramesh R.
, Roth J.A.
, Sadeghi T.
, Sepulveda C.A.
, Shen A.C.
, Shpall E.
, University Texas MD Anderson Cancer Center, US
An active clinical trial at MD Anderson Cancer Center uses DOTAP:Chol liposomes as a non-viral vector for gene therapy. This therapeutic product needs to be produced fresh for each administration. Originally, the manufacture of the [...]
Reactive oxygen species (ROS), derived from the metabolism of oxygen and exist inherently in all aerobic organisms, lead to oxidative damage in a cell, tissue, or organ. This damage can affect a specific molecule or [...]
Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) - a novel pH/temperature sensitive and biodegradable hydrogel copolymer used for drug and protein delivery was synthesized. Bovine insulin (BI) and human growth hormone (HGH) loaded well to the copolymer [...]
Fe3O4 nanoparticles (NPs) was first synthesized via coprecipiatation. After synthesis and purification of the Fe3O4 NPs, poly(acrylic acid) (PAA) was coated on them at specified conditions. The coating process is not possible at pH higher [...]
Hormone Peptide Conjugated Ironoxide Nanoparticles For Detection and Treatment of Metastases LEUSCHNER C1, KUMAR C2, Hansel W 1,BRANCA RT3, GALIANA G3, WARREN WS3 , HORMES F2. 1Pennington Biomedical Research Center, Baton Rouge, LA, USA, 2Center [...]
A thermosensitive grafted polymeric system which can be triggered to release the loaded drug with an increase in temperature, induced by a magnetic thermal heating event (Brazel et al., 2006) was developed. The desirable carrier [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery