Papers:
Targeted Nanoparticle-Polypeptide Conjugates for Breast Cancer Treatment
Alexis F., Basto P., Radovic-Moreno A., Langer R., Farokhzad O.C., Brigham and Women's Hospital, Harvard Medical School, US
We have developed a polymeric targeted nanoparticle-polypeptide conjugates that shows cell binding speficity and stealth properties. The targeted naoparticles binds and are taken up efficiently by Her2 expressing breast cancer cells. These nanoparticles represent a [...]
A Targeted Nanotechnology-based Therapeutic System for the Combined Chemoprevention of Colon Cancer
Colorectal cancer (CRC) is the second most common cause of cancer death in the USA. Current research is shifting the focus from chemotherapy to chemoprevention. The overall goal was to develop a low dose, novel [...]
Polymer Nanospheres for Improved Drug Delivery of Protein Therapeutics and Viral Antigens
Biologically adherent polymeric microsphere carriers have been shown to be effective in the oral delivery of proteins such as insulin and DNA plasmids. These microspheres are comprised of hydrophobic copolymers that appear to have a [...]
Targeted Aptamer-Nanoparticles to Diminish Drug Resistance of Cancer Cells in vitro Study
Basto P., Alexis F., Levy-Nissenbaum E., Langer R., Farokzhad O., Massachusetts Institute of Technology, US
Using prostate cancer as a model, we report the drug release of pacitaxel and doxorubicin from aptamer-poly (D,L lactic co glycolic acid)-poly(ethylene glycol) (PLGA-PEG) nanoparticles used to target prostate-specific membrane antigen (PSMA), a well characterized [...]
Specific targeting and delivery of virus envelope-coated nanoparticle cargoes into receptor-bearing cells and subcellular compartments
We build on our recently reported work in Nano letters describing coating of nanoparticle cargoes with virus envelope proteins to show that the method works for viruses other than ecotropic murine leukemia viruses. We also [...]
Self –assembled Nanoparticles of Dextrin Substituted with Hexadecanethiol
Amphiphilic molecules, such as surfactants or lipids, spontaneously self-assemble in water, forming self-aggregates, such as micelles, bilayer membranes, tubes and vesicles. Amphiphilicity of biopolymers is one of the most important factors for their self-organization in [...]
Oral Macrophage Mediated Gene Delivery System
The efficiency of non-viral gene delivery is dependent on 4 factors: DNA protection, DNA delivery across membranes, endosomal DNA release, and nuclear uptake. Here we report on the development of a new delivery technology based [...]
Galactosidase Gene Expression in Yeast Cells Enhanced by Nanoparticles
We report the enhancement of gene expression for rice -galactosidase gene (-Gal) in yeast cells assisted by metal nanomaterials. Au and Ag nanoparticles, and their nanocomposites, silica@Au and silica@Ag were prepared and characterized by UV-vis [...]
Mechanism of Action and Surfactant Influence During Chemotherapy of Brain Tumour Using Doxorubicin-Loaded Poly(Butyl Cyanoacrylate) Nanoparticles
Petri B., Bootz A., Khalanski A., Hekmatara T., Müller R., Kreuter J., Gelperina S., Moscow Medical Academy, RU
Polysorbate 80(Tween® 80)-coated poly(butyl cyanoacrylate) nanoparticles have been shown to enable the transport of doxorubicin (DOX) across the blood-brain barrier (BBB). This formulation produced a high antitumoral effect in an orthotopic model of the very [...]
Biodegradable Nanoparticles Effect on Drug Delivery System
Recently, it is very mortal that so many percentages of people get infected with chronic hepatitis as increasing trend and consequently leaded to the death because of a complication arises of cirrhosis and liver cancer. [...]
Spectroscopical and Structural Studies of Sol-gel Reservoirs used as Implants in the Delivery of Dopamine to the Central Nervous System
The stabilization of dopamine used in the treatment of Parkinsons is a pressing problem. When dopamine is applied systemically. destabilization may occur following penetration through the blood brain barrier (BBB). In order to circumvent this [...]
The Effect of Water on Particle Size, porosity, and the Rate of Drug Release from Implanted Titania Resrvoirsia
Lopez T., Hernandez-Ayala A., Odriozola J.A., Quintana P., Gonzalez R.D., Lottici P.P., Marino I., Tulane University, US
In this study, sol-gel titania implants used in the controlled rate of drug release of valproic acid to the temporal lobe of the brain were optimized to insure that the correct drug dose is delivered. [...]
An implantable Drug Delivery Device based on MEMS
An implantable biochip based on MEMS (Micro-Electro-Mechanical-Systems) was developed to treat hemorrhagic shock in the battlefied. We discuss the design, fabrication, and testing of the device. In addition, we describe an animal model validating the [...]
Synthesis of superparamagnetic magnetite nanoparticles for thermoresponsive drug delivery
Superparamagnetic magnetite nanoparticles (MNPs) were synthesized via modified coprecipitation method and their physical properties were examined. The crystal structure of Fe3O4 nanoparticles (NPs) was confirmed by X-ray diffraction. From the dynamic laser scattering analysis, the [...]
Synthesis of Biocompatible Nanocomposite hydrogels as a Local Drug Delivery System
Bako J., Szepesi M., Borbely J., Borbely Z.M., Hegedus C., Borbely J., Borbely Z.M., University of Debrecen, HU
Hydrogels are three dimensional hydrophilic crosslinked polymer networks, which capable of swelling in water. They have soft and elastic nature, which suggests similarities to natural tissues. Hydrogels are important in dentistry. For example, PerioChip is [...]
Establishing a GMP manufacturing site for nanoparticles
Sepulveda C.A., Roth J.A., Lu C., Ji L., Ramesh R., O’Connor S., Sadeghi T., Flagge F., Baez O., Shen A.C., Mondesir E., Jenkins J., Shpall E., McMannis J.D., University Texas MD Anderson Cancer Center, US
An active clinical trial at MD Anderson Cancer Center uses DOTAP:Chol liposomes as a non-viral vector for gene therapy. This therapeutic product needs to be produced fresh for each administration. Originally, the manufacture of the [...]
In Vivo Protein Transduction: Penetration of the Biologically Active HIV-1 Tat Mediated Cu,Zn-Superoxide Dismutase Rescues Murine Skin from Oxidative Stress
Liu T-P, Chen C-T, Chen Y-P, Chou C-M, Chang Y-C, Chiu T-T, Chen C-T, Chen Y-P, Taipei Medical University, TW
Reactive oxygen species (ROS), derived from the metabolism of oxygen and exist inherently in all aerobic organisms, lead to oxidative damage in a cell, tissue, or organ. This damage can affect a specific molecule or [...]
New carrier for protein and drug delivery based on injectable Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) pH/temperature hydrogel
Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) - a novel pH/temperature sensitive and biodegradable hydrogel copolymer used for drug and protein delivery was synthesized. Bovine insulin (BI) and human growth hormone (HGH) loaded well to the copolymer [...]
Hyperhtermia effect of surface-modified magnetite nanoparticles in a microfluid system
Fe3O4 nanoparticles (NPs) was first synthesized via coprecipiatation. After synthesis and purification of the Fe3O4 NPs, poly(acrylic acid) (PAA) was coated on them at specified conditions. The coating process is not possible at pH higher [...]
Hormone Peptide Conjugated Ironoxide Nanoparticles For Detection and Treatment of Metastases
Leuschner C., Kumar C., Hansel W., Branca R.T., Galiana G., Warren W., Hormes F., Pennington Biomedical Research Center, US
Hormone Peptide Conjugated Ironoxide Nanoparticles For Detection and Treatment of Metastases LEUSCHNER C1, KUMAR C2, Hansel W 1,BRANCA RT3, GALIANA G3, WARREN WS3 , HORMES F2. 1Pennington Biomedical Research Center, Baton Rouge, LA, USA, 2Center [...]
Development of a Magnetically Triggered Drug Delivery System using Thermoresponsive Grafted Polymer Networks with Magnetic Nanoparticles
A thermosensitive grafted polymeric system which can be triggered to release the loaded drug with an increase in temperature, induced by a magnetic thermal heating event (Brazel et al., 2006) was developed. The desirable carrier [...]
Journal: TechConnect Briefs
Volume: 2, Technical Proceedings of the 2007 NSTI Nanotechnology Conference and Trade Show, Volume 2
Published: May 20, 2007
Industry sector: Medical & Biotech
Topics: Biomaterials, Materials for Drug & Gene Delivery
ISBN: 1-4200-6183-6