Papers:
Bacteria Inhibitory Action of Peptides P753 and P359 in 2D and 3D Cell Cultures
The current study investigated two proprietary peptides, p359 and p753, for their antibacterial activity against Escherichia coli (E.Coli) and Staphylococcus aureus (S. aureus). Minimum Inhibitory Concentration (MIC) of bacteria for p359 and p753 was 50μg/mL [...]
Remote control of mechano-sensory function of primary cilia by Fe2O3 nanoparticles in ciliopathic animal models
In the present studies, we designed a cilia-targeted delivery system to deliver fenoldopam (FD) specifically to the primary cilia. Hence, we devised the iron oxide nanoparticle (Fe2O3-NP)-based technology for ciliotherapy. Dynamic light scattering measurements showed [...]
Accelerated Neutral Atom Beam processing of medical devices enhances tissue integration while reducing bacterial attachment
Accelerated Neutral Atom Beam (ANAB) technology is a low energy accelerated particle beam gaining acceptance as a tool for nano-scale surface modification of implantable medical devices. ANAB is created by acceleration of 2. METHODS neutral [...]
Discriminated properties of PEI functionalized gold nanoparticles (Au-PEIs) predetermined by synthetic routes of ligand exchange and reduction processes: Paths and Fates
Cho T.J., Gorham J.M., Pettibone J.M., Hackley V.A., National Institute of Standards and Technology, US
Polyethyleneimine (PEI) functionalized AuNPs (Au-PEIs) have potential use as positively charged gold nanoparticles (AuNPs) for nano-medicinal applications, due to their cationic surfaces that promote cellular uptake and gene transfection.1-6 Au-PEIs can be prepared by one [...]
Cytotoxic Effects of Short Multi-Wall Carbon Nanotubes on Pancreatic Cancer Cells
Lai J.C.K., Desai V., Zhang Y., Bhushan A., Leung S., Idaho State University College of Pharmacy, US
Although carbon nanotubes (CNTs) are increasingly exploited in diverse industrial and biomedical applications, their health hazard to humans is poorly understood. We have developed many cell models in vitro to systematically study the putative cytotoxicity [...]
Enhancement of Effects of Chitosan and Nanoparticles on Pancreatic Cancer Cells by Combination Treatments with the Anti-Cancer Drug Adriamycin
Because of chitosan’s roles in biomedical applications, this study investigated the effects of chitosan, chitosan in combination with silver or gold nanoparticles, and chitosan with nanoparticles and Adriamycin, Methotrexate or Cisplatin on human PANC-1 pancreatic [...]
Personalized nanomedicine for the treatment of vascular hypertension in polycystic kidney disease models
In our current study, we designed a nanomedical device for the treatment of vascular hypertension in polycystic kidney disease (PKD) model through cilia targeting. We generated and compared two different metal and polymer cilia-targeted nanoparticle [...]
M2D2: a successful model catalyzing medical device innovation and development
Hafer N., McManus D., Picard M., Tello, S., University of Massachusetts Center for Clinical and Translational Science, US
The Massachusetts Medical Device Development (M2D2) center offers inventors and small medical device companies coordinated access to research, engineering, and clinical investigation at the UMass Medical School (UMMS) and UMass Lowell (UML) campuses. UMMS provides [...]
A Biomedical Sensor Based on Resonant Absorption of Ultrasound Waves in Hydrogel-based Resonators
Smart hydrogels can be tailored to undergo a vol- ume change in response to an analyte. The potential biocompatibility of these materials has made them a very promising material for biomedical sensing applica- tions. To [...]
Air Powered Artifical Lungs and other High Efficiency Fluid Reactor Innovations
Commercially available Hollow Fiber (HF) based Extracorporeal Membrane Oxygenators (ECMO) are presently being built using a parallel assembly of over 10- 20K of porous hollow polymeric fibers as respective reactor core elements (RCE). They are [...]
An electrostimulation cell device with patterned TiO2: Nb thin films as bio-electrodes
Jobin M., Pellodi C., Sandu C., Benvenutti G., Sandoz A., Stoppini L., hepia / HES-SO University of Applied Sciences of Western Switzerland, CH
We present a cellular test device based on Nb:TiO2 (niobium dooped titania) transparent conductive oxide (TCO) as bio-electrodes. The device is intended to easily provide electrical stimuli to a given cell tissue and to monitor [...]
Nanobiomimetic Structured Organo-Metal Devices Direct Rapid Real-time Monitor Atto Molarities of ATP in Biological Specimens
Real-time monitoring of ATP in biological specimens is a convenient means to monitor the hygiene in healthcare units and for medical devices. Rapid and precise monitoring of ATP has been in strong demand. We report [...]
Catalytic Nanoparticles to Enhance the Sensitivity of Lateral Flow Immunoassays
Lateral-flow immunoassays (LFIAs) are a widely used point- of-care technology. They are most familiar as home-pregnancy tests, but are also employed for testing for a wide variety of diseases, biomarkers, and even small molecules. By [...]
An ultrasensitive and culture-free detection platform for microorganisms and protein biomarkers
We have developed an electrochemical immunoassay platform, which detects a range of disease-related targets including bacteria, viruses, fungi and protein biomarkers. The platform features a voltage-controlled signal amplification, which leads to ultrasensitive detection. The analytical [...]
Journal: TechConnect Briefs
Volume: TechConnect Briefs 2019
Published: June 17, 2019
Industry sector: Medical & Biotech
Topics: Biomaterials, Diagnostics & Bioimaging
ISBN: 978-0-9988782-8-7