Discriminated properties of PEI functionalized gold nanoparticles (Au-PEIs) predetermined by synthetic routes of ligand exchange and reduction processes: Paths and Fates

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Polyethyleneimine (PEI) functionalized AuNPs (Au-PEIs) have potential use as positively charged gold nanoparticles (AuNPs) for nano-medicinal applications, due to their cationic surfaces that promote cellular uptake and gene transfection.1-6 Au-PEIs can be prepared by one of two methods: (1) ligand modification (exchange or co- attachment) of AuNPs and PEI, or (2) reduction of AuIII ions in the presence of PEI. Herein, the ligand exchanged Au- PEIs (Au-PEI[LE]s) and the materials by reduction (Au- PEI[Red]s) were prepared from citrate-stabilized AuNPs (10 nm, nominal) and HAuCl4, respectively. We demonstrate differentiated product formation via each synthetic route and their discriminated physico-chemical properties by systematic examination. The physico- chemical properties and the conjugation mechanisms of Au- PEI[LE] and Au-PEI[Red] were characterized by orthogonal analyses system. Furthermore, the colloidal stabilities of all produced Au-PEIs were investigated under various physiologically relevant conditions and shown that the consequential fates ‒ property and colloidal stability ‒ of Au-PEIs were dependent on born pathways significantly. We found that some of Au-PEIs showed outstanding colloidal stability in certain circumstances which is very critical to be a drug carrier in nanomedicine.

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Journal: TechConnect Briefs
Volume: TechConnect Briefs 2019
Published: June 17, 2019
Pages: 393 - 396
Industry sector: Medical & Biotech
Topics: Biomaterials, Diagnostics & Bioimaging
ISBN: 978-0-9988782-8-7