Papers – Page 22 – TechConnect Briefs

ROS Evaluation for Series of CNTs Using the ESR Method and the Effects of CNT Mophology

Tsuruoka S., Takeuchi K., Koyama K., Endo M., Fujisawa K., Matsumoto H., Saito N., Usui Y., Porter D.W., Castranova V., Shinshu University, JP

Carbon nanotubes (CNTs) are becoming important materials in industry. It is a concern that CNTs may induce carcinogenic responses through pulmonary exposure. It has been recently reported1-6 that CNTs scavenge ROS depending on their morphology. [...]

Oxidatively Induced Damage to DNA: Potential Roles of Single- and Multi-Wall Carbon Nanotubes at the Molecular Level

Nelson B.C., National Institute of Standards and Technology, US

Carbon nanotubes (CNTs) are remarkable materials in terms of their enhanced thermal and electrical conductivities, tensile strengths and mechanical properties. Because of these unique properties, the commercial development and application of CNTs in electronics, advanced [...]

Toxic Potential of Food-Relevant Nanoparticles in the Intestinal Epithelium

McCracken C., Zane A., Knight D., Dutta P., Waldman W.J., The Ohio State University, US

Oral exposure to nanoparticles incorporated in foods is increasingly common. However, the effects of these nanoparticles when ingested are still unknown. Thus, this investigation tested the hypothesis that nanoparticle toxicity is dependent on particle size, [...]

Cytotoxicity and biointeractions of nanosilver in macrophages

Pratsinis A., Pratsinis S.E., Hervella P., Leroux J.-C., Pratsinis A., Pratsinis S.E., Sotiriou G.A., ETH Zürich, CH

Silver nanoparticles (nanosilver) are broadly used today in textiles, food packaging, household devices and bioapplications, prompting a better understanding of their toxicity and biological interactions. Here, nanosilver of well-defined size (5.7 to 20.4 nm) supported [...]

Zinc Oxide Nanoparticles Induced Apoptosis and Necrosis in Hepatocellular Carcinoma HepG2 Cells

Tadinada S.M., Lai J.C.K., Lai M.B., Idikuda V.K., Mukka K., Singh M.R.M., Pfau J., Bhushan A., Leung S.W., Lai J.C.K., Lai M.B., Idaho State University College of Pharmacy, US

Targeted drug delivery systems with minimal potential adverse/side effects are gaining utility in diverse applications. Uses of nanomaterials to design such targeted drug delivery are escalating exponentially. Nevertheless, the biocompatibility of nanomaterials is inadequately addressed. [...]

Titanium Dioxide Nanoparticles Interaction, Uptake and Genotoxicty in Salmonella typhimurium Bacteria

Casey B.J., Butler K.S., Elespuru R.K., Dair B.J., U.S. Food and Drug Administration, US

Due to their unique properties the use of nanoparticles (NPs) in consumer products is increasing rapidly. The expanding prevalence of NPs make it critical to understand the associated risk to both the public health along [...]

A safer-by-design formulation concept for flame-generated engineered nanomaterials

Gass S., Pyrgiotakis G., Cohen J.M., Sotiriou G.A., Pratsinis S.E., Demokritou P., Harvard School of Public Health, US

As more consumers and factory workers become exposed to engineered nanomaterials (ENMs), the question of exposure risks is rapidly gaining importance. Engineering less toxic ENMs that maintain valuable functional properties is therefore crucial to the [...]

Cellular uptake and cytotoxic effect of broccoli phytochemical based gold nanoparticles (B-AuNPs): Enhanced cancer therapeutic efficacy

Khoobchandani M., Katti K., Katti K.V., Zambre A., Katti K., Katti K.V., University of Missouri, US

The interaction phytochemicals from Broccoli with gold salt results in dual reduction and surface capping to produce well-defined stable and biocompatible gold nanoparticles. The core sizes of B-AuNPs are in the range of 10–20 nm [...]

pH Responsive Polymeric Nanoparticles Fabricated by Dispersion Polymerization as a Platform for the Delivery of Anticancer Drugs

Puri R., Berhe S., Akala E., Howard University, US

In diseased conditions such as tumors, pH is slightly more acidic than in the blood. The endocytic pathway of cells begin near the physiological pH of 7.4, but it drops to a lower pH of [...]

The Development of Stealth Poly-Ɛ-Caprolactone Nanoparticles For the Delivery of Bioactive Agents

Ogunwuyi O., Akala E., Howard University, US

Polyesters have gained a lot of prominence because of their use in drug delivery. They are the most widely used polymers in biomedical applications because they are biocompatible, non-immunogenic, non-toxic and are approved for use [...]