Papers – Page 23 – TechConnect Briefs

Synthesis of amphiphilic block copolymers to deliver HSP90 inhibitors for colorectal tumors

Lin C.Y., Shieh M.J., National Taiwan University, TW

In this article, we present pH-sensitive and small size nanoparticles as carrier to encapsulate 17-AAG. We anticipate that this platform will provide a new strategy for cancer therapy.

Lipopolymeric nanoparticles: platform technology for aerosolized combination chemotherapy

Kaur S., Banerjee R., Indian Institute of Technology - Bombay, IN

In the present study, we have conceptualized and formulated a novel delivery vehicle which includes a combination of lipid nanovesicles and polymeric nanoparticles. Main aim of the study is to devise a nanoscale platform technology [...]

Superparamagnetic Iron Oxide Nanoparticles as Drug Delivery Vehicles

Vig K., Casey K., Tiwari P.M., Miller M., Samant R., Singh S.R., Alabama State University, US

In recent years, nanotechnology has emerged as one of the most promising fields for biomedical applications and healthcare. The use of nanoparticles has earned much attention due to their small size, high surface area to [...]

Highly sensitive detection of cancer biomarker EGFR by PicoTREC-SERS

Xiao L., Harihar S., Wu Y., Welch D.R., Zhou A., Utah State University, US

It is reported that for women in the U.S., breast cancer death rates are higher than those for any other cancer, besides lung cancer. Considering the fact that approximately 70–80% of breast carcinomas overexpress the [...]

Metastatic diagnosis of colon cancer by vertically aligned carbon nanotube based electromechanical biosensor

Abdolahad M., Taghinejad H., Taghinejad M., Taghinejad H., Taghinejad M., Janmaleki M., Mohajerzadeh S., University of Tehran, IR

vertically aligned carbon nanotube based electrical biosensor was demonstrated as a more rapid, sensitive and specific device for metastatic diagnosis of colon cancer cells based on the mechanical entrapment of metastatic cancer cells on vertically [...]

Bio-imaging of colorectal cancer models using a CK19-bioconjugated Quantum Dot Nanoprobe

Gazouli M., Nikiteas N., Anagnou NP., Kelekis N., Efstathopoulos E., School of Medicine University of Athens, GR

The aim of the study was to develop and validate a QD-nanoprobe for the detection of CK19 protein for in vivo colorectal cancer molecular targeting. QDs with a maximum emission wavelength of 655 nm, were [...]

Isolation and Detection of Cancer Related DNA Nanoparticulate Biomarkers Directly from CLL Patient Blood “Rapid Sample to Sequence Diagnostics”

Heller M.J., Marciniak J., Sonnenberg A., University of California San Diego, US

The analysis of cell free circulating (cfc) DNA biomarkers continues to become more widely used for cancer diagnostics and management. Cfc-DNA ranges from nucleosomes and high molecular weight DNA nanoparticulates to 100-200bp fragments. We have [...]

Effects of Titanium Dioxide Nanoparticles (TiO2) on Behavioral Parameters of Rats

Rihane Ben Younes N., Amara S., Mrad I., Omri K., El Ghoul J., El Mir L., El Ghoul J., El Mir L., Jeljeli M., Ben Rhouma K., Abdelmelek H., Sakly M., Faculty of Sciences, TN

Titanium dioxide nanoparticles (TiO2-NPs) have a wide range of applications in many fields. The effects of TiO2 NPs on the central nervous system are still unclear. The present study, we investigated the effects of sub-acute [...]

Cationic polystyrene nanosphere induces autophagy through inhibition of Akt/mTOR and activation of AMPK signaling pathways in macrophage and epithelial cells

Chiu H-W, Xia T., Tsai J-C, Chen C-W, Wang Y-J, National Cheng Kung University, Medical College, TW

Nanoparticles have been used to produce a wide range of products. Those include applications in imaging and drug delivery in medicine. However, the possible adverse biological effects in human being remain unclear. Autophagy is an [...]

Pharmacokinetics and Safety Studies of Low Molecular Weight Heparin Nanoconjugates

Yang T., Bouchard B., Cook A., Hu J., Hao J., Bai S., Husson University, US

Low molecular weight heparins (LMWHs) have received widespread acceptance as the first choice for initial prevention and treatment of venous thromboembolism via subcutaneous injection one to two times daily in the clinic. The need for [...]