Papers – Page 25 – TechConnect Briefs

Plasmonic Nanobubbles for Intracellular Targeting and Gene Therapy

Lukianova-Hleb E., Wen J., Meteletsa L., Brenner M., Chang J., Lapotko D.O., Rice University, US

Intracellular molecular targeting (IMT) and gene transfection of eukaryotic cells is widely used for research and for developing gene cell therapy. However, the existing IMT methods lack selectivity, efficacy and safety when heterogeneous cell systems [...]

Gene Delivery and Transfection in Human Pancreatic Cancer Cells using Epidermal Growth Factor Receptor-Targeted Gelatin Nanoparticles

Xu J., Amiji M., Northeastern University, US

More than 32,000 patients are diagnosed with pancreatic cancer in the United States per year and the disease is associated with very high mortality. Although gene therapy has tremendous promise, the major challenge has been [...]

Hybrid bionanomaterials based on nanocrystalline TiO2 and catechol-grafted polymers: the effect of composition and morphology on photo and bioactivity

Cellesi F., University of Manchester, UK

We proposed a synthetic strategy for producing hybrid bionanomaterials based on nanocrystalline TiO2 and catechol-grafted polymers. A sol-gel process in organic solvent was developed to grow TiO2 nanocrystals of highly controlled size and surface chemistry, [...]

Characterization of Nanostructural Modifications Introduced into a Model Pectic Homogalacturonan by Esterases or Chemical Saponification and Modeling of Enzyme Mode of Action

Cameron R.G., Luzio G.A., Kim Y., Vasu P., Savary B.J., Williams M.A.K., United States Department of Agriculture, Agricultural Research Service, US

Pectin functionality is largely dependent on the ratio of methylesterified/demethylesterified galacturonic acid (GalA) residues present in its polymeric homogalacturonan region (40 – 60 nm in length, 100 – 150 GalA residues) and how the two [...]

Nanostructured TiO2 and TiO2-Ag antimicrobial thin films

Prasad R.G.S.V., Basavaraju D., Rao K.N., Naveen C.S., Endrino J., Phani A.R., Sri Vishnu College of Pharmacy, IN

Bacterial infection is one of the common clinical problems which can be prevented by coating the surgical instruments or implants with antibacterial properties. The high incidence of infections caused by either fungal or bacteria on [...]

Nanoskin Bacterial cellulose structured- Towards the development of regenerative medicine

Olyveira G.M., Costa L.M.M., Basmaji P., UFABC, BR

Bacterial cellulose (BC) has established to be a remarkably versatile biomaterial and can be used in wide variety of applied scientific endeavors, especially for medical devices. In fact, biomedical devices recently have gained a significant [...]

Synthesis and Characterization of Anti-CD4 monoclonal antibody-conjugated Magnetic Poly (glycidyl methacrylate) Particles and their Application on CD4+ Lymphocyte Separation

Pimpha N., Chaleawlert-umpon S., Chruewkamlow N., Kasinrerk W., National Nanotechnology Center, TH

To develop an efficient magnetic system for separation of CD4+ lymphocytes, we design a simple, specific, and cost-effective CD4 separation system without the need for column separation technique. Novel immunomagnetic particles have been prepared for [...]

Antioxidant activity of fullerene C60 against OH free radicals: A Quantum Chemistry and Computational Kinetics Study

Iuga C., Universidad Autónoma Metropolitana, MX

Fullerenes are considered to be the world’s most efficient radical scavenger, and represents an attractive tool for biological applications. Indeed, it have been demonstrated in vivo and in vitro, that fullerenes and related structures reduce [...]

Three-dimensional cell instructive scaffolds to direct stem cell fate

Viswanathan P., Chirasatitsin S., Reilly G., Engler A., Battaglia G., University of Sheffield, UK

Novel biomaterials design rarely incorporates the range of topographical (10nm – 100um) and chemical cues required to influence cell behaviour. Of particular interest is controlling human mesenchymal and embryonic stem cell fate. Recently it has [...]

Titanium Tungsten Coatings for Bioelectrochemical Applications

Wierzbicki R., Amato L., Lopacinska J., Heiskanen A., Emneus J., Boggild P., Molhave K., DTU Nanotech, DK

Our research interest is the combination of carbon nanotube electrochemistry with nanostructured substrates capable of cell scaffolding. Therefore, an adhesion / electric connection coating with good biocompatibility, PECVD compatibility and electrochemical stability needs to be [...]