TechConnect Proceedings Papers
Month: March 2004
High Throughput in-silico Screening against Flexible Protein Receptors
Virtual screening of chemical databases to targets of known three-dimensional structure is developing into an increasingly reliable method for finding new lead candidates in drug development. Both better scoring functions and novel docking strategies contribute [...]
Internalization of Nanoparticles in the Middle Ear Epithelium in Response to an External Magnetic Field: Generating a Force
In this study we report the first generation of force by long-term intracellular magnetic nanoparticles (MNP) using a guinea pig middle ear model. Synthesis of magnetite nanoparticles was done using a modified precipitation technique. We [...]
pH Dependent Optical Properties of Surface Modified Gold Nanoparticles Using a Bovine Serum Albumin Coating
Xu Y., Linares K.A., Meehan K., Love B.J., Love N.G., Love B.J., Love N.G., Virginia Polytechnic Institute and State University, US
Use of gold nanoparticles has significant potential in biosensors. Gold’s surface plasmon resonance (SPR) is influenced by the refractive index of the surrounding environment. Changes in the SPR signal can be correlated to changes in [...]
Viruses as Optical Probes
Viruses consist of a nucleic acide core, the genome, and a protein shell, the viral capsid. Although made out of only a few types of molecular building blocks, virus capsids exhibit a complex set of [...]
Nanosecond Pulsed Electric Fields Trigger Intracellular Signals in Human Lymphocytes
We present evidence for a new technological approach to signaling and triggering of intracellular events in biological cells. Remotely applied nanosecond, megavolt-per-meter, pulsed electric fields perturb the intracellular environment, causing calcium release, phosphatidylserine externalization, and [...]
Development of a Self-Assembled Muscle-Powered Piezoelectric Microgenerator
As technology advances into a new era of N/MEMS, powering these tiny devices becomes a significant issue. To address this issue, a self-assembled living/nonliving microgenerator has been developed through seamless integration of PVDF-TrFE and neonatal [...]
Forisomes: Mechano-Proteins that Exert Force in Contraction and Expansion
Knoblauch M., Noll G.A., Prüfer D., Jaag H., Fontanellaz M.E., Schneider-Hüther I., van Bel A.J.E., Peters W.S., Fraunhofer Institute IME, DE
Motor-proteins are the basis of the dynamic three dimensional organization of the living cell. Most motor-proteins are driven by energetically favorable reactions such as ATP hydrolysis. We here describe anisotropic contractility in forisomes, protein bodies [...]