Papers – Page 43 – TechConnect Briefs

PCR Micro-Voume Device for Detection of Nucleic Acids

Auroux P-A, Day P., Niggli F., Manz A., Kinderspital, CH

The polymerase chain reaction (PCR) is an enzyme-mediated nucleic acid amplifer process that is employed extensively throughout the medical and biological sciences. The technique has risen to acclaim largely through its exquisite sensitivity, but an [...]

Molecular Recognition on Demand

Sherrill C., Marshall D., Richmond C., Scherrer C., Prudent J.R., EraGen Bioscience, Inc., US

DNA is the only chemistry that allows for ?molecular recognition on demand?. That is, unlike any other molecular recognition chemistry, DNA allows for the simple design and rapid synthesis of molecule sets that will recognize [...]

Nanoscale Bio-Molecular Control Using EC-OWLS

Bearinger J.P., Vörös J., Spencer N.D., Hubbell J.A., Textor M., ETH Zürich/ Lawrence Livermore National Laboratory, US

A new technique has been developed that combines evanescent-field optical sensing with electrochemical control of surface adsorption processes. This technique, termed Electrochemical Optical Waveguide Lightmode Spectroscopy (EC-OWLS), proved efficient in monitoring molecular surface adsorption and [...]

Stochastic Tunneling Method for High Throughput Database Screening

Merlitz H., Burghardt B., Wenzel W., Forschungszentrum Karlsruhe, DE

Virtual screeing of large databases of chemical compounds against known structurally resolved protein receptors emerges as a promising route for lead discovery in drug design. In this approach each ligand of the database is aligned [...]

Freeze-fracture Electron Microscopy on Nanostructures for Drug & Gene Delivery

Papahadjopoulos-Sternberg B., NanoAnalytical Laboratory, US

The potency of drug/gene-loaded carriers is frequently depending upon their morphology adopted in a biological relevant environment. Freeze-fracture electron microscopy/1/ is not only a powerful technique to characterize drug/gene carrier on a nanometer resolution scale/2,4-11/ [...]

Month: February 2003

PCR Micro-Voume Device for Detection of Nucleic Acids

Molecular Recognition on Demand

Nanoscale Bio-Molecular Control Using EC-OWLS

Stochastic Tunneling Method for High Throughput Database Screening

Freeze-fracture Electron Microscopy on Nanostructures for Drug & Gene Delivery

Replica Exchange Molecular Dynamics Toolkit for Drug-receptor Docking

CONFLEX: Conformational Behaviors of Polypeptides as Predicted by a Conformational Space Search

cDNA Microarray Data Based Classification of Cancers Using Neural Networks and Genetic Algorithms

A Computational Efficient Algorithm for Protein Sequence Classification

Syntenic Reconstruction of Microbial Chromosomal Mutations