Papers – Page 44 – TechConnect Briefs

Mathematical Modeling the Dynamics of Recombinant Endonuclease Production in Microsystems

Ohtaguchi K., Asami K., Tokyo Institute of Technology, JP

A mathematical model for the dynamics of micro-scale production of recombinant human DNase I is formulated. In experiments extracellular production of human DNase I gene product from methylotrophic yeast Pichia pastoris GS115 has been achieved. [...]

Converging Technologies (NBIC)

Bainbridge W.S., National Science Foundation, US

The convergence of nanotechnology, biotechnology, information technology and cognitive science can greatly improve human performance over the next ten to twenty years. The chief areas of application include: expanding human cognition and communication, improving human [...]

A Fokker-Planck Approach For Modeling Integrated NanoBio Systems

Jenkins J.W., Sundaram S., CFD Research Corporation, US

Physics-based, high-fidelity simulations have emerged as indispensable tools in the design of complex, microfluidic devices (lab-on-chip). However, ab-initio analysis becomes increasingly complicated as the dimensions of the device approach nanoscales and molecular information/interactions must be [...]

Biologically Inspired Controls over Assembly of Crystalline Nanostructures

De Yoreo J.J., Orme C.A., Qiu R., Dove P.M., Lawrence Livermore National Laboratory, US

By utilizing small molecules and proteins to modulate crystal nucleation and growth, living organisms produce single nanocrystals and nanocrystal composites that exhibit control over the location, phase and crystallographic orientation of the nuclei, as well [...]

DNA base damage: A Car-Parrinello Molecular Dynamics Study of Guanine and Thymine with an OH Radical

Wu Y., Mundy C.J., Colvin M.E., Car R., Lawrence Livermore National Labs, US

Understanding the basic chemistry of radicals and DNA bases is an important step in characterizing the potential damage to DNA. The chemical level understanding of such damage has far reaching implications for radiation therapy, health [...]

Electrohydrodynamic Interactions of an AFM Tip and a Biological Membrane

Fan T.H., Fedorov A.G., Georgia Institute of Technology, US

In biological applications, AFM imaging needs to be performed in the natural (aqueous) living environment of the cell in order to observe molecular level interactions and biochemical processes in-situ in the electrolyte solution and to [...]