Syntenic Reconstruction of Microbial Chromosomal Mutations


Keywords: , ,

In this paper, we propose a method to reconstruct the evolutionary history of chromosomal modifications between groups of related species using conservation of synteny. Starting from the most closely related species, as defined by the currently established taxonomy for microbial species, a minimal parsimony class of chromosomal events can be built. This class contains three types of regions: regions that are completely conserved, regions with some form of chromosomal modification, for example a gene duplication or deletion, and regions with an inversion. From this data alone, it is not possible to determine which chromosome form is ancestral, but using a closely related lineage these ambiguities can be resolved. In this way an ancestral genome arrangement can be determined for clades of species and then these classes can be aligned to resolve regional ambiguities.

PDF of paper:

Journal: TechConnect Briefs
Volume: 1, Technical Proceedings of the 2003 Nanotechnology Conference and Trade Show, Volume 1
Published: February 23, 2003
Pages: 21 - 23
Industry sector: Medical & Biotech
Topics: Biomaterials, Informatics, Modeling & Simulation
ISBN: 0-9728422-0-9