Micro & Bio Fluidics, Lab-on-Chip – Page 46

Electrode Shapes for Electrowetting Arrays

Lienemann J., Greiner A., Korvink J.G., Albert Ludwig University, DE

We calculate the potential energy of an electrowetting array for different shapes and sizes of interdigital edge structures. To understand the dynamic effects at the beginning of the droplet motion is crucial for the optimization [...]

Low Energy Conformations of a Three-Helix Peptide in a All-Atom Biomolecular Forcefield

Herges Th., Schug A., Wenzel W., Forschungszentrum Karlsruhe, DE

Protein structure prediction remains one of the main outstanding challenges of theoretical biophysical chemistry. Its goal is to predict the fully three-dimensional tertiary structure of the protein on the basis of its amino acid sequence [...]

Highly Integrated Transparent Microchannel Chips for Continuous-flow PCR

Sun K., Matsuo S., Misawa H., Satellite Venture Business Laboratory, The University of Tokushima, JP

A microchannel chip for continuous-flow polymerase chain reaction (PCR) was developed using transparent materials. The microchannel was fabricated on a quartz glass substrate using standard photolithography and wet-etching techniques, and was sealed by another quartz [...]

Lab-on-Chip

Macromolecules in Microdevices: Multiscale simulation of DNA dynamics in model microfluidic geometries

Jendrejack R.M., de Pablo J.J., Graham M.D., University of Wisconsin-Madison, US

Simple arguments predict that the dynamics of a dissolved macromolecule confined to a channel comparable to its equilibrium coi size (~1 um for viral DNA) are quite different from those in free solution, because of [...]

Simulation Methodology for Dielectrophoresis in Microelectronic Lab-on-a-chip

Leonardi A., Medoro G., Manaresi N., Tartagni M., Guerrieri R., DEIS - University of Bologna, IT

Recent trends in lab-on-a-chip show a growing use of dielectrophoresis (DEP) to manipulate biological objects such as cells and organic molecules [1], [2], [3], [4]. Bringing the advances of microelectronic miniaturization into biological and clinical [...]

Biochemical Binding in Microspheres-Based-Imunoassays

Prabhakarpandian B., Shah K.B., Sundaram S., Makhijani V.B., CFD Research Corporation, US

Microspheres (referred commonly as beads) are being extensively used in biochemical assays as supports for proteins, DNA, etc. We have successfully developed |omputational models for simulating sample detection using flowing beads. The model fully integrates [...]

Separation of Long Polyelectrolytes in a Microfuluidic Channel with Constrictions: A Monte Carlo Study

Tessier F., Slater G.W., University of Ottawa, CA

We present Monte Carlo simulation results for the motion of long linear polyelectrolytes inside a microchannel of molecular dimensions, structured as a periodic array of wells linked by narrow constrictions. Molecules are driven in the [...]

Squeezing Flow of Particles and Large Molecules Suspended in a Liquid Through Nanochannels

Acrivos A., Khusid B., Koplik J., Drazer G., New Jersey Institute of Technology, US

The presentation addresses the status of current understanding of the hydrodynamic phenomena accompanyin the motion of a nanometer-sized particle through a nanotube.

Direct Numerical Simulation of Moving Charged, Flexible Bodies with Thermal Fluctuations

Patankar N.A., Northwestern University, US

The interaction of sub-micron scale objects with fluids is an important problem encountered in miniaturized systems. Various physical phenomena should be modeled simultaneously for a fundamental investigation of these systems. Our objective is to develop [...]