Materials for Drug & Gene Delivery

Nanodelivery of Cerebrolysin Induces Profound Neuroprotection in Heat Stroke Following Chronic Hypertension in Combination with SiO2 and Carbon Nanoparticles Induced Exacerbation of Brain Damage

Muresanu D.F., Sharma A., Sharma H.S., Patnaik R., Nozari A., Mössler H., Tian Z.R., Ozkizilcik A., Sharma A., Sharma H.S., Uppsala University, SE

Our military personals are often exposed to combat stress induced hypertension in an environment rich in various nanoparticles emanating from different sources e.g., gun powder explosion or blast injuries. Furthermore, combat or peacekeeping activity in [...]

Nanomedicine in Neurodegenerative Disorders: understanding the journey

Tosi G., Ruozi B., Vilella A., Grabrucker A.M., Belletti D., Vandelli M.A., Boeckers T.M., Forni F., Zoli M., Sharma A., Sharma H.S., Muresanu D.F., Sharma A., Sharma H.S., Uppsala University, SE

The novelty of the last 3 years of research is on the fate of NPs made of poly-lactic-co-glycolic acid (PLGA) and engineered with g7, a glycopeptide that enhances BBB crossing capability, in the living mouse [...]

Thermally responsive lipid coated superparamagnetic nanoparticles for frequency triggered drug delivery

Patil-Sen Y., Eizadi Sharifabad M., Mercer T., Bond G., Patil-Sen Y., Sen T., University of Central Lancashire, UK

In this abstract, we report a series of novel thermally responsive lipid coated core-shell mesoporous silica-superparamagnetic iron oxide nanoparticles as drug delivery vehicles for potential use for cancer therapy under magnetic hyperthermia. Hydrophilic anticancer drug [...]

Efficient drug delivery for cancer treatment using amine-functional SiO2-LDH nanocomposites

Li L., Liu J., Gu W.Y., Gu Z., Gu W.Y., Gu Z., Liu J., Xu Z.P., Australian Institute for Bioengineering and Nanotechnology, AU

Target-specific delivery and sustained release of anticancer agents and siRNA has attracted considerable research interest in cancer chemotherapy. Recently, we have developed layered double hydroxide (LDH) vector to efficiently deliver drug and siRNA into the [...]

HA-decorated nanoparticles as tumour-targeting nucleic acids carriers

Tirella A., Rios J.M., Tirelli N., University of Manchester, UK

The design of tools that allow for a targeted delivery of therapeutic cargos have a great potential in the treatment of many pathological conditions (e.g. cancer and autoimmune diseases). In the context of nucleic acids [...]

Electrospun nanofibers for Sustained Delivery of Cetylpyridinium Chloride for Buccal Topical Application

Zanin M.H.A., Santos V.A., Oliveira A.M., Cerize N.N.P., Borsatti M.A., Institute for Technological Research of the State of São Paulo - IPT, BR

The aim of this study was to prepare electrospun polymeric nanofiber mat composed of polyvinylpyrrolidone (PVP-Kollidon® 90F), ammonio methacrylate copolymer type B (PMMA-Eudragit® RS100) and cetylpyridinium chloride (CPC), 10:10:1 (wt/wt%) and its characterization for buccal [...]

Nitric oxide releasing PLGA microspheres for biomedical applications

Lautner G., Schwendeman S.P., Meyerhoff M.E., University of Michigan, US

In the current work, we encapsulated an S-nitroso species in biodegradable poly(lactic-co-glycolic acid (PLGA) microspheres (with diameter of 20-125 µm) that release nitric oxide (NO) for weeks in a continuous and controlled manner. The rate [...]

Engineering of Recombinant Spider Silk Proteins Allows Defined Drug Uptake and Release

Scheibel T., Unibersity of BAyreuth, DE

Drug delivery systems allow tissue / cell specific targeting of drugs in order to reduce total drug amounts administered to an organism and potential side effects upon systemic drug delivery. Most drug delivery systems are [...]

Inductive Nano Targeted Electromagnetic Therapy

Meymanat M., Zanjan University of Medical Sciences, Zanjan, Iran, IR

A Biofunctionalized conductor Nano-Particle which can be made of ferromagnetic and conductor materials, capable to attach specifically biologic targets in vivo and in vitro by using molecules for specific attachment (such as monoclonal antibody) is [...]