Materials for Drug & Gene Delivery – Page 25

A Targeted Nanotechnology-based Therapeutic System for the Combined Chemoprevention of Colon Cancer

Prabhu S., Kanthamneni N., College of Pharmacy, Western University of Health Sciences, US

Colorectal cancer (CRC) is the second most common cause of cancer death in the USA. Current research is shifting the focus from chemotherapy to chemoprevention. The overall goal was to develop a low dose, novel [...]

Targeted Nanoparticle-Polypeptide Conjugates for Breast Cancer Treatment

Alexis F., Basto P., Radovic-Moreno A., Langer R., Farokhzad O.C., Brigham and Women's Hospital, Harvard Medical School, US

We have developed a polymeric targeted nanoparticle-polypeptide conjugates that shows cell binding speficity and stealth properties. The targeted naoparticles binds and are taken up efficiently by Her2 expressing breast cancer cells. These nanoparticles represent a [...]

Drug Delivery

Nanotechnology and the Water Market: Applications and Health Effects

Mowat F.S., Tsuji J., Exponent, US

Nanotechnology has an enormous potential for creating cost-effective, simple, and efficient tools for addressing water supply challenges, while preventing the creation of potentially toxic by-products. Applications include water disinfection and filtration, real-time and remote monitoring, [...]

Economic and Environmental Tradeoffs in SWNT Production

Healy M.L., Tanwani A., Isaacs J.A., Northeastern University, US

Assessment of economic and environmental attributes of nanomanufacturing during process development has significant potential to contribute to the quality and effectiveness of the processes, and will lead to development of competitive, safe and environmentally responsible [...]

Preparation and Characterization of Various Nanofluids

Williams W.C., Bang I.C., Forrest E., Hu L.W., Buongiorno J., Massachusetts Institute of Technology, US

As part of an effort to evaluate water-based nanofluids for nuclear applications, preparation and characterization has been performed for nanofluids being considered for MIT’s nanofluid heat transfer experiments. Three methods of generating these nanofluids are [...]

Interaction between Artificial Mucin Layer and Stimuli-Responsive Nanogel Particles for the Oral Peptide Delivery Observed in Simulated Intestinal Solutions by Using Colloid Probe AFM Method

Kamiya H., Yoshimura M., Tsukada M., Ichikawa H., Fukumori Y., Tokyo University of Agriculture and Technology, JP

In order to characterize and control the adhesive behaviors of nanometer scaled stimuli-responsible gel particles designed for oral peptide delivery, their interaction with artificial mucin layer in the small intestinal solutions was determined by the [...]

Dicationic gemini surfactant gene delivery complexes contain cubic-lamellar mixed polymorphic phase

Foldvari M., Wettig S., Badea I., Verrall R., Bagonluri M., University of Saskatchewan, CA

The characterization of structural properties of novel dicationic (gemini) surfactant-based DNA complexes as micro/nano-scale self-assembling delivery systems for cutaneous gene therapy is described and discussed as related to measured transfection efficiencies. Previous small-angle x-ray scattering [...]

Sensing and Plotting Single Molecule Binding Events with the Atomic Force Microscope

Johnson W.T., Molecular Imaging, US

SPM/AFM (scanning probe microscopy/atomic force microscopy) offers many unique advantages to the study of biological process at the nanometer scale. ASM/AFM allows scientists to visualize, probe, and analyze the structure of biological molecules in their [...]

Construction of Enzymosomes: Optimization of Coupling Parameters

Vale C.A., Corvo M.L., Martins L.C.D., Martins M.B.F., Marques C.R., Storm G., Cruz M.E.M., Martins L.C.D., Martins M.B.F., Laboratorio Nacional de Engenharia, Tecnologia e Inovacao, IP, PT

Different strategies can be used to improve carrier mediated delivery of therapeutic proteins. The incorporation of therapeutic enzymes into polymeric carriers [1], into aqueous space of lipid vesicles [2] or lipid-detergent vesicles [3, 4] or [...]