Topic: Materials for Drug & Gene Delivery
Development of a Magnetically Triggered Drug Delivery System using Thermoresponsive Grafted Polymer Networks with Magnetic Nanoparticles
A thermosensitive grafted polymeric system which can be triggered to release the loaded drug with an increase in temperature, induced by a magnetic thermal heating event (Brazel et al., 2006) was developed. The desirable carrier [...]
Hormone Peptide Conjugated Ironoxide Nanoparticles For Detection and Treatment of Metastases
Leuschner C., Kumar C., Hansel W., Branca R.T., Galiana G., Warren W., Hormes F., Pennington Biomedical Research Center, US
Hormone Peptide Conjugated Ironoxide Nanoparticles For Detection and Treatment of Metastases LEUSCHNER C1, KUMAR C2, Hansel W 1,BRANCA RT3, GALIANA G3, WARREN WS3 , HORMES F2. 1Pennington Biomedical Research Center, Baton Rouge, LA, USA, 2Center [...]
Hyperhtermia effect of surface-modified magnetite nanoparticles in a microfluid system
Fe3O4 nanoparticles (NPs) was first synthesized via coprecipiatation. After synthesis and purification of the Fe3O4 NPs, poly(acrylic acid) (PAA) was coated on them at specified conditions. The coating process is not possible at pH higher [...]
New carrier for protein and drug delivery based on injectable Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) pH/temperature hydrogel
Poly(ethylene glycol)-Poly(?- caprolactone)-Poly(?-amino ester) (PAE-PCL-PEG-PCL-PAE) - a novel pH/temperature sensitive and biodegradable hydrogel copolymer used for drug and protein delivery was synthesized. Bovine insulin (BI) and human growth hormone (HGH) loaded well to the copolymer [...]
In Vivo Protein Transduction: Penetration of the Biologically Active HIV-1 Tat Mediated Cu,Zn-Superoxide Dismutase Rescues Murine Skin from Oxidative Stress
Liu T-P, Chen C-T, Chen Y-P, Chou C-M, Chang Y-C, Chiu T-T, Chen C-T, Chen Y-P, Taipei Medical University, TW
Reactive oxygen species (ROS), derived from the metabolism of oxygen and exist inherently in all aerobic organisms, lead to oxidative damage in a cell, tissue, or organ. This damage can affect a specific molecule or [...]
Establishing a GMP manufacturing site for nanoparticles
Sepulveda C.A., Roth J.A., Lu C., Ji L., Ramesh R., O’Connor S., Sadeghi T., Flagge F., Baez O., Shen A.C., Mondesir E., Jenkins J., Shpall E., McMannis J.D., University Texas MD Anderson Cancer Center, US
An active clinical trial at MD Anderson Cancer Center uses DOTAP:Chol liposomes as a non-viral vector for gene therapy. This therapeutic product needs to be produced fresh for each administration. Originally, the manufacture of the [...]
Synthesis of Biocompatible Nanocomposite hydrogels as a Local Drug Delivery System
Bako J., Szepesi M., Borbely J., Borbely Z.M., Hegedus C., Borbely J., Borbely Z.M., University of Debrecen, HU
Hydrogels are three dimensional hydrophilic crosslinked polymer networks, which capable of swelling in water. They have soft and elastic nature, which suggests similarities to natural tissues. Hydrogels are important in dentistry. For example, PerioChip is [...]
Synthesis of superparamagnetic magnetite nanoparticles for thermoresponsive drug delivery
Superparamagnetic magnetite nanoparticles (MNPs) were synthesized via modified coprecipitation method and their physical properties were examined. The crystal structure of Fe3O4 nanoparticles (NPs) was confirmed by X-ray diffraction. From the dynamic laser scattering analysis, the [...]
An implantable Drug Delivery Device based on MEMS
An implantable biochip based on MEMS (Micro-Electro-Mechanical-Systems) was developed to treat hemorrhagic shock in the battlefied. We discuss the design, fabrication, and testing of the device. In addition, we describe an animal model validating the [...]