Chemical, Physical & Bio-Sensors – Page 29

The Use of Quartz Crystal Microbalance in Cell Differentiation Detection

Shih C-J, Ke W-W, Lieu C-H, Industrial Technology Research Institute/Electronics Research & Service Organization, TW

We try to investigate whether the hematopoietic cell differentiation can be detected by Quartz Crystal Microbalance. Because certain hematopoietic transcription factors play a critical role in cell differentiation and lineage determination, they can be alternate [...]

Microcantilever Array Sensor for DNA and RNA Detection

Cherian S., Natesan M., Macis E., Cain R., Tedeschi L., Citti L., Palchetti I., Tombelli S., Raiteri R., University of Genova, IT

A microcantilever array platform is used for the detection of DNA hybridization and mRNA using selected immobilized oligonucleotides. Parallel detection on sixteen cantilevers are carried out simultaneously. The immobilization procedure and the results of the [...]

Signal Amplification of Surface Plasmon Resonance based on Gold Nanoparticle-Antibody Conjugate and its Application to Protein Array

Lee D-B, Lee W., Lee D-B, Lee W., Kim Y-W., Choi J.W., Sogang University, KR

Nanoparticles have offered many diverse capabilities in bioanalysis and biotechnological applications, due to the intrinsic properties of nanoparticle that is distinguished from bulk materials. The integration of nanoparticle, which exhibit unique electronic, photonic, and catalytic [...]

Synthesis of new Metal Complex – Biomolecule Hybrids as Redox Sensors for Specific Nucleobases

Gasser G., Bond A.M., Graham B., Kosowski Z., Spiccia L., Monash University, AU

There are a number of redox-active supramolecular receptors described in the literature, but those containing ferrocene as a redox-active reporter group are the most frequently cited. It has been shown that modified ferrocenyl conjugates can [...]

Plasmon-enhanced Fluorescence Detection of Blood Metabolites in Biosensors

Klitgaard S., Rasmussen T., Neves-Petersen M.T., Neves-Petersen M.T., Petersen S.B., Aalborg University, DK

Quick and precise detection of blood metabolites is a key parameter in monitoring and treating critically sick patients. Each analysis requires a certain amount of blood, and especially for babies in neonatal care repeated sampling [...]

Characterization of a Tethering System for Biosensor Applications

Blasi L., Pompa P.P., Pisignano D., Palazzo G., Mallardi A., Maruccio G., Maffei A., Ciccarella G., Vasapollo G., Calabi F., Cingolani R., Rinaldi R., Leece University, IT

The immobilization of brain dopamine receptors on a solid support can represent an appealing strategy for the realisation of a sensing element for dopamine and dopaminergic drugs. Brain dopamine receptors are the primary targets in [...]

Nano-Cantilevers for an Ultra-Sensitive Bio-Assay

Zheng J., Klein K., Pucha R., Sitaraman S.K., Sitaraman S.V., Merlin D., Rajalakshmi S., Sarma D.S.R., Gerwirtz A., Sitaraman S.K., Sitaraman S.V., Georgia Institute of Technology, US

Micro and Nano-scale cantilever arrays are being developed for an ultra sensitive bio-assay (Figure 1). The advantage of these cantilevers is that they eliminate the use of laser for deflection detection, which is impractical for [...]

New Light Induced Molecular Switch allows Sterically Oriented Micrometer Sized Immobilization of Biomolecules

Snabe T., Neves-Petersen M.T., Fojan P., Klitgaard S., Neves-Petersen M.T., Petersen S.B., Aalborg University, DK

Fundamental knowledge on protein structures and the effect of ultraviolet light on these structures has paved the way for the development of a unique light-based immobilization technology that allows oriented protein immobilization onto micrometer sized [...]

Surface Characterization of a Direct, Label-Free Piezoelectric Immunosensor Platform

Papadopoulou-Bouraoui A., Lejeune M., Barrero-Moreno J., Valsesia A., Manso M., Gilliland D., Ceccone G., Rossi F., European Commission - JRC, IT

During this study the QCM (Quartz Crystal Microbalance) crystal surface was functionalized in order to provide active amino groups, and serve as an active platform for antibody immobilization and the development of direct, label-free immunosensors. [...]

Nanobiodevices Integrating Biomolecular Motors

Ramachandran S., Wu D., Nitta T., Tucker R., Phillips A., Hess H., University of Washington, US

Biomolecular motors, such as the motor protein kinesin, can serve as force-generating modules in hybrid nanodevices. We will present recent progress in utilizing these motors for nanoscale transport of target reagents and discuss applications, such [...]