Biomaterials – Page 20 – TechConnect Briefs

Synthesis and evaluation of T85-LPEI copolymers for pDNA delivery

Wang M.X., Carolinas Medical Center, US

In this study, a series of low molecular weight PEI (LPEI) modified with Tween 85 were prepared by varying feed ratio and PEI size (Mw: 0.8k, 1.2k and 2.0k Da) for gene delivery. The Mws [...]

Biodegradable Polymer-Based Composite Particles for Targeted Drug Delivery Carriers with Magnetic Response

Kitamoto Y., Oka C., Ushimaru K., Tsuge T., Horiishi N., Tokyo Institute of Technology, JP

Core–shell composite particles with biodegradability and magnetism were prepared for targeted drug delivery based on magnetic guidance. The composite particles were composed of a core of biodegradable polymer and a shell of assembled magnetic iron [...]

Shell Thickness Control of Mesoporous Silica Hollow Capsules and Their Release Behavior

Yamaguchi Y., Kato N., Meiji university, JP

we propose the method to control the shell thickness of the mesoporous silica hollow capsules (MSHCs) and the method to load the materilas into the MSHCs. The release behavior was also invesitgated. The template-assisted method [...]

Applying Plasmon Resonant Coating to Commercial Liposomal Delivery Systems

Knights-Mitchell S.S., University of Arizona, US

Multiple drug-encapsulated liposomes have been successfully marketed as pharmaceuticals within the past two decades. Some of these liposomal drugs have been shown to selectively localize within tumors. However, one limitation is the inability to control [...]

Nano-Power Implantable Autonomous Closed-Loop CMOS Nerve-Growth-Factor Delivery Microsystem for Neurological Disorders Personalized Therapy

Poustinchi M., Musallam S., McGill University, Neural Prosthetics Laboratory, CA

480 million patients around the globe suffer from neurological disorders which are the fastest-growing disease worldwide. Many neurological and psychiatric conditions are the result of abnormal neurotransmitter concentrations in the brain. Our ultimate goal is [...]

TiO2-Nanowired cerebrolysin attenuated hyperthermia induced ubiquitin overexpression and brain pathology

Sharma A., Sharma H.S., Muresanu D.F., Patnaik R., Moessler H., Sharma A., Sharma H.S., Uppsala University, SE

1. Hyperthermia and heat stress induces brain damage. This is specially applicable to Military personals during combat operations in the Middle East where heat is a big problem 2. Intoxication of nanoparticles exacerbates heat-induced brain [...]

How does nanoparticle design affect targeting selectivity: computer modeling

Dormidontova E.E., University of Connecticut, US

One of the areas of active development of modern nanomedicine is application of polymer tethered nanoparticles for drug/gene delivery and imaging. The optimal nanoparticle design for targeting one type of cell may be quite different [...]

Materials for Drug & Gene Delivery & Cancer Nanotech

Preparation and characterization of starch nanoparticles by desolvation method

Uzun S., Kokini J.L., University of Illinois, US

Nanoparticles prepared from biocompatible and biodegradable materials have attracted considerable attention in food and pharmaceutical science. Starch is one of abundant biopolymer. In this study, starch nanoparticles were produced by desolvation method and the influence [...]

Chemiresistive hydrogen (H2) gas sensor based on viral-templated Pd nanowires

Moon C.H., Yan Y., Zhang M., Myung N.V., Haberer E.D., University of California Riverside, US

Palladium (Pd) has been widely used for H2 sensing applications because it readily forms a solid solution with hydrogen, modifying electrical resistance. Because the resistance change is diffusion-limited, Pd nanostructured materials with large surface area [...]