Sensors, MEMS, Electronics – Page 195

DNA-DNA Interaction on Dendron-Functionalized Sol-Gel Silica Films Followed with Surface Plasmon Fluorescence Spectroscopy

Kwon S.H., Hong B.J., Park H.Y., Park J.W., Knoll W., Park H.Y., Park J.W., Center for Integrated Molecular System., KR

Since we observed that dendron-assembled surface providing a proper spacing between immobilized DNAs showed high single nucleotide polymorphism discrimination efficiency for DNA microarrays(1), the nanoscale-controlled surface is examined with surface plasmon field-enhanced fluorescence spectroscopy (or [...]

Homogeneous Bioluminescence Resonant Energy Transfer On High Density Array Imaging Chip

Filanoski B., Rastogi S., Cameron E., Mishra N., Maki W., University of Idaho, US

Fluorescent microarray technologies are widely used in molecular biology for studying gene expression, immune detection and drug discovery. Fluorescent assays are very sensitive but present problems with many bio-agents having inherent fluorescence which interfere with [...]

SERS Nanotags for Point-of-Care Diagnostics

Natan M., Oxonica, US

A holy grail in point-of-care diagnostics is to develop tests that perform on par with the central laboratory in terms of robustness, multi-analyte capability, precision, and sensitivity. Oxonica has developed a series of proprietary, nanoscale [...]

Nanoplex(TM) Biotags: Near-IR Excited, Highly Multiplexed Nanoparticulate Optical Detection Tags for Diagnostic Assays

Penn S., Cromer R., Sha M., Doering B., Brown B., Norton S., Walton I., Oxonica Inc, US

Oxonica Inc has developed a novel optical detection tag for use in point of care diagnostics, cellular imaging assays, and life science assays. Nanoplex(TM) Biotags are silica coated Au nanoparticles that, by virtue of surface [...]

Peptide Nucleic Acids Modified Nano-Biosensor for Early Cancer Diagnosis

Rastogi S., Mishra N., Winterrowd P., Nelson R., Maki W., University of Idaho, US

Epigenetics is proving to have an increasingly important role in both human development and disease, particularly cancer. DNA methylation is one of two epigenetic alterations. A distinct set of tumor types has a high level [...]

Rapid Isothermal Amplification and Multiplexed Surface Detection of Short DNA Sequences

Tan E., Han Y., Kniazeva E., Buechel M., Erwin B., Niemz A., Keck Graduate Institute, US

We have coupled a novel isothermal amplification method for short oligonucleotides (EXPAR) with solution and surface-based detection involving DNA-functionalized gold nanospheres. In these assays, a trigger oligonucleotide is exponentially amplified and converted to a reporter [...]

DNA Detection Using Metal-Fluorescence Interactions on Two-Dimensionally Assembled Gold Nanoparticles

Nakahara M., Taniguchi S., Inoue T., Hitachi Ltd., JP

We developed a novel DNA detection system using a single stranded probe oligonucleotide with a fluorophore immobilized on two-dimensionally assembled gold nanoparticles. This system enables the detection of amplified DNAs without fluorescence labeling. In the [...]

Biosensors

High Quality Nanogap Electrodes for Electronic Transport Measurements of Single Molecules

Johnston D.E., Strachan D.R., Guiton B.S., Davies P.K., Johnson A.T., University of Pennsylvania, US

Single molecule-based electronic devices hold the potential for higher density and higher performance applications in medicine, sensing, computing and photovoltaics. Experimentally, metal-molecule-metal (MMM) junctions provide a system for measuring molecular electronic properties directly. We developed [...]

A Quasimolecular Approach to the Field-effect Molecular Transistor: Theory and Application

Zhao Y.-L., Allison T., Mujica V., Gonzalez C., Marquez M., NIST Center for Theoretical and Computational Nanosciences, US

DFT-based modified quasimolecular approach has been developed and implemented for studying molecular conductance successfully, in the case of molecular bridges attached to metal electrodes (Gonzalez et al. J. Phys. Chem. B. 2004, 108, 18414). In [...]