Sector: Medical & Biotech
Use of PBMC Partitioning to Predict RES-Uptake of a Nanoemulsion in a Colon Cancer Xenograft
Devalapally H., Clogston J.D., Amiji M.M., McNeil S., Stern S.T., SAIC-Frederick, National Cancer Institute at Frederick, US
Nanotechnology platforms have emerged as versatile carrier systems for delivery of active molecules to tumors. Nanoparticle-based formulations have demonstrated enhanced efficacy and decreased toxicity in comparison to conventional drugs. These carrier systems often encounter rapid [...]
Carbon Nanotubes as Molecular Nanocarriers for Antibody Delivery and Photothermal Ablation of Breast Cancer Cells
In this paper, the utilization of carbon nanotubes as nanocarriers for antibody delivery to IGF1R and HER2 surface receptors and selective thermal ablation of breast cancer cells is presented. IGF1R and Her2 surface receptors are [...]
Method of LANTCET for cancer diagnostics and treatment at cell level
Hleb E.Y., Zastinskaya I.A., Ilyukova I.I., Semenenya I.N., Hafner J.H., Hanna E.Y., Myers J.N., Zhdanok S.A., Lapotko D.O., A. V. Lykov Heat & Mass Transfer Institute, BY
We have developed the method of LANTCET (laser-activated nano-thermolysis as a cell elimination technology) for selective detection and destruction of individual tumor cells by generating intracellular photothermal bubbles around the clusters of gold nanoparticles. Bare [...]
PMMA/SWCNTs Composites for Prostate Brachytherapy MRI Contrast Agent Markers
Prostate brachytherapy (PB) is an alternative to traditional external beam radiation or surgery for men who have prostate cancer. PB used implanted radioactive titanium seeds and has increased in popularity over recent years due to [...]
Anticancer Iron Oxide Nanoparticles
Benyettou F., Lalatonne Y., Sainte-Catherine O., Lecouvey M., Motte L., Laboratoire CSPBAT FRE 3043 CNRS, FR
We designed a new therapeutic nanoplatform which could be both imaged in situ with MRI (T2 contrast agent) and/or addressed by magnetic targeting (magnet) or specific molecules (peptides, antibodies …). The biological in-vitro tests performed [...]
Epirubicin hydrochloride loaded poly (butyl cyanoacrylate) nanoparticles: formulation optimization, characterization and in vitro evaluation on human breast cancer cell lines
Dantuluri P.R., Shah N.M., Murthy R.S.R., Kumar M.R.S., Rao B.S.S., The M.S. University of Baroda, IN
Breast cancer is the second leading cause of deaths in women today after lung cancer, the mortality rate of patients with breast cancer around the world is rising steadily over time. Metastatic spread is the [...]
Preliminary studies of new photosensitizer for photodynamic treatment of melanoma based on nanostructural forms of Bacteriochlorin p N-alkoxycycloimide alkoxyoxyme methyl ester
Meerovich G.A., Meerovich I.G., Meerovich G.A., Meerovich I.G., Grin M.A., Pozdeyev V.I., Tsiprovskij A.G., Oborotova N.A., Loschenov V.B., Yu.Baryshnikov A., Mironov A.F., A.M. Prokhorov General Physics Institute of RAS, RU
This work is devoted to investigation of Bacteriochlorin p N-alkoxycycloimide alkoxyoxyme methyl ester which possesses its absorption band at 795-800 nm. We have estimated the applicability of PDT with this photosensitizer to treat melanoma. We [...]
Role of Ultrasound in Anti-Cancer Drug Delivery Loaded on Microspheres
Targeting is a new therapeutic tool for malignant tumor as a result of combining nanotechnology with chemotherapeutics. Ultrasound has been shown to enhance degradation and drug delivery from biodegradable and non biodegradable polymeric devices. If [...]
The development of multicolor panels with Quantum Dots-conjugated antibodies for diagnostics of Chronic Lymphoid Leukemia (CLL) by conventional flow cytometer
Diagnostics of leukemia and lymphomas by flow cytometry emerged in 90-th years of last century when several consensus panels had been introduced and based on three-four color cytometry. The standard flow diagnostics approach requires 10-15 [...]