Medical & Biotech – Page 25 – TechConnect Briefs

TiO2 Nanowired Cerebrolysin enhances neuroprotective effects of mesenchymal stem cells following concussive head injury at hot environments

Sharma A., Sharma H.S., Muresanu D.F., Feng L., Lafuente J.V., Patnaik R., Tian Z.R., Ozikzilcik A., Mössler H., Sharma A., Sharma H.S., Uppsala University, SE

Concussive head injury (CHI) could lead to either instant death or lifetime disabilities. Our soldiers are highly vulnerable to CHI during combat operations. Thus, to treat these soldiers effectively novel strategies using combination therapy is [...]

Mn nanoparticles exacerbates closed head injury induced blood-brain barrier disruption, brain pathology, and sensory motor dysfunctions. Neuroproetction by Nanowired delivery of 5-HT2 receptor antagonists Ketanserin and Ritanserin

Sharma A., Sharma H.S., Feng L., Muresanu D.F., Lafuente J.V., Tian Z.R., Ozkizilcik A., Smith M.A., Sharma A., Sharma H.S., Uppsala University, SE

This innovation deals with adverse effects of Mn nanoparticles on brain pathology in concussive head injury. Also Mn nanoparticles treatment alters therapeutic modalities. The novel data presented in the abstract show that Mn exposure to [...]

TiO2 nanowired delivery of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) induces profound neuroprotection in concussive head injury

Feng L., Sharma A., Sharma H.S., Yin H., Lafuenta J.V., Ozkizilcik A., Tian Z.R., Sharma A., Sharma H.S., Bethune International Peace Hospital, CN

To develop suitable therapeutic strategies for concussive brain injury (CHI), we have explored the role of a Chinese traditional medicine DL-3-n-butylphthalide (DL-NBP) in a rat model. We delivered this compound alone and also using Titanium [...]

Nanodelivery of Cerebrolysin Induces Profound Neuroprotection in Heat Stroke Following Chronic Hypertension in Combination with SiO2 and Carbon Nanoparticles Induced Exacerbation of Brain Damage

Muresanu D.F., Sharma A., Sharma H.S., Patnaik R., Nozari A., Mössler H., Tian Z.R., Ozkizilcik A., Sharma A., Sharma H.S., Uppsala University, SE

Our military personals are often exposed to combat stress induced hypertension in an environment rich in various nanoparticles emanating from different sources e.g., gun powder explosion or blast injuries. Furthermore, combat or peacekeeping activity in [...]

Nanomedicine in Neurodegenerative Disorders: understanding the journey

Tosi G., Ruozi B., Vilella A., Grabrucker A.M., Belletti D., Vandelli M.A., Boeckers T.M., Forni F., Zoli M., Sharma A., Sharma H.S., Muresanu D.F., Sharma A., Sharma H.S., Uppsala University, SE

The novelty of the last 3 years of research is on the fate of NPs made of poly-lactic-co-glycolic acid (PLGA) and engineered with g7, a glycopeptide that enhances BBB crossing capability, in the living mouse [...]

Thermally responsive lipid coated superparamagnetic nanoparticles for frequency triggered drug delivery

Patil-Sen Y., Eizadi Sharifabad M., Mercer T., Bond G., Patil-Sen Y., Sen T., University of Central Lancashire, UK

In this abstract, we report a series of novel thermally responsive lipid coated core-shell mesoporous silica-superparamagnetic iron oxide nanoparticles as drug delivery vehicles for potential use for cancer therapy under magnetic hyperthermia. Hydrophilic anticancer drug [...]

Efficient drug delivery for cancer treatment using amine-functional SiO2-LDH nanocomposites

Li L., Liu J., Gu W.Y., Gu Z., Gu W.Y., Gu Z., Liu J., Xu Z.P., Australian Institute for Bioengineering and Nanotechnology, AU

Target-specific delivery and sustained release of anticancer agents and siRNA has attracted considerable research interest in cancer chemotherapy. Recently, we have developed layered double hydroxide (LDH) vector to efficiently deliver drug and siRNA into the [...]

HA-decorated nanoparticles as tumour-targeting nucleic acids carriers

Tirella A., Rios J.M., Tirelli N., University of Manchester, UK

The design of tools that allow for a targeted delivery of therapeutic cargos have a great potential in the treatment of many pathological conditions (e.g. cancer and autoimmune diseases). In the context of nucleic acids [...]

Electrospun nanofibers for Sustained Delivery of Cetylpyridinium Chloride for Buccal Topical Application

Zanin M.H.A., Santos V.A., Oliveira A.M., Cerize N.N.P., Borsatti M.A., Institute for Technological Research of the State of São Paulo - IPT, BR

The aim of this study was to prepare electrospun polymeric nanofiber mat composed of polyvinylpyrrolidone (PVP-Kollidon® 90F), ammonio methacrylate copolymer type B (PMMA-Eudragit® RS100) and cetylpyridinium chloride (CPC), 10:10:1 (wt/wt%) and its characterization for buccal [...]

Nitric oxide releasing PLGA microspheres for biomedical applications

Lautner G., Schwendeman S.P., Meyerhoff M.E., University of Michigan, US

In the current work, we encapsulated an S-nitroso species in biodegradable poly(lactic-co-glycolic acid (PLGA) microspheres (with diameter of 20-125 µm) that release nitric oxide (NO) for weeks in a continuous and controlled manner. The rate [...]