Medical & Biotech – Page 125 – TechConnect Briefs

In Vivo Protein Transduction: Penetration of the Biologically Active HIV-1 Tat Mediated Cu,Zn-Superoxide Dismutase Rescues Murine Skin from Oxidative Stress

Liu T-P, Chen C-T, Chen Y-P, Chou C-M, Chang Y-C, Chiu T-T, Chen C-T, Chen Y-P, Taipei Medical University, TW

Reactive oxygen species (ROS), derived from the metabolism of oxygen and exist inherently in all aerobic organisms, lead to oxidative damage in a cell, tissue, or organ. This damage can affect a specific molecule or [...]

Establishing a GMP manufacturing site for nanoparticles

Sepulveda C.A., Roth J.A., Lu C., Ji L., Ramesh R., O’Connor S., Sadeghi T., Flagge F., Baez O., Shen A.C., Mondesir E., Jenkins J., Shpall E., McMannis J.D., University Texas MD Anderson Cancer Center, US

An active clinical trial at MD Anderson Cancer Center uses DOTAP:Chol liposomes as a non-viral vector for gene therapy. This therapeutic product needs to be produced fresh for each administration. Originally, the manufacture of the [...]

Synthesis of Biocompatible Nanocomposite hydrogels as a Local Drug Delivery System

Bako J., Szepesi M., Borbely J., Borbely Z.M., Hegedus C., Borbely J., Borbely Z.M., University of Debrecen, HU

Hydrogels are three dimensional hydrophilic crosslinked polymer networks, which capable of swelling in water. They have soft and elastic nature, which suggests similarities to natural tissues. Hydrogels are important in dentistry. For example, PerioChip is [...]

Synthesis of superparamagnetic magnetite nanoparticles for thermoresponsive drug delivery

Lin C.Y., Ho K.C., National Taiwan University, TW

Superparamagnetic magnetite nanoparticles (MNPs) were synthesized via modified coprecipitation method and their physical properties were examined. The crystal structure of Fe3O4 nanoparticles (NPs) was confirmed by X-ray diffraction. From the dynamic laser scattering analysis, the [...]

An implantable Drug Delivery Device based on MEMS

Elman N.M., Ho Duc H-L, Cima M.J., Massachusetts Institute of Technology, US

An implantable biochip based on MEMS (Micro-Electro-Mechanical-Systems) was developed to treat hemorrhagic shock in the battlefied. We discuss the design, fabrication, and testing of the device. In addition, we describe an animal model validating the [...]

The Effect of Water on Particle Size, porosity, and the Rate of Drug Release from Implanted Titania Resrvoirsia

Lopez T., Hernandez-Ayala A., Odriozola J.A., Quintana P., Gonzalez R.D., Lottici P.P., Marino I., Tulane University, US

In this study, sol-gel titania implants used in the controlled rate of drug release of valproic acid to the temporal lobe of the brain were optimized to insure that the correct drug dose is delivered. [...]

Spectroscopical and Structural Studies of Sol-gel Reservoirs used as Implants in the Delivery of Dopamine to the Central Nervous System

Lopez T., Esquivel D., Ascencio J., Odriozola J.A., Gonzalez R.D., Tulane University, US

The stabilization of dopamine used in the treatment of Parkinsons is a pressing problem. When dopamine is applied systemically. destabilization may occur following penetration through the blood brain barrier (BBB). In order to circumvent this [...]

Biodegradable Nanoparticles Effect on Drug Delivery System

Kim B.G., Kang I.J., Kyungwon University, KR

Recently, it is very mortal that so many percentages of people get infected with chronic hepatitis as increasing trend and consequently leaded to the death because of a complication arises of cirrhosis and liver cancer. [...]

Mechanism of Action and Surfactant Influence During Chemotherapy of Brain Tumour Using Doxorubicin-Loaded Poly(Butyl Cyanoacrylate) Nanoparticles

Petri B., Bootz A., Khalanski A., Hekmatara T., Müller R., Kreuter J., Gelperina S., Moscow Medical Academy, RU

Polysorbate 80(Tween® 80)-coated poly(butyl cyanoacrylate) nanoparticles have been shown to enable the transport of doxorubicin (DOX) across the blood-brain barrier (BBB). This formulation produced a high antitumoral effect in an orthotopic model of the very [...]

Galactosidase Gene Expression in Yeast Cells Enhanced by Nanoparticles

Chien S-F, Chen S-H, Lin C-T, Northern Illinois University, US

We report the enhancement of gene expression for rice -galactosidase gene (-Gal) in yeast cells assisted by metal nanomaterials. Au and Ag nanoparticles, and their nanocomposites, silica@Au and silica@Ag were prepared and characterized by UV-vis [...]