Medical & Biotech – Page 122 – TechConnect Briefs

Preparation of multifuctional nanofibrous scaffold for tissue engineering

Yang X., Ogbolu K.R., Wang H., Stevens Institute of Technology, US

Multifucntional fibrous scaffolds can be produced via layer-by-layer deposition of electrospun nanofibers containing variable function. This scaffolds can be used in tissue engineering of complex structure by allowing specific controlled microenvironment for heterogeneous cell types.

Bio Materials and Tissues

Interaction of carbon nanotube material with rat skin by 21 T MRI

Sharma R., Shetty K., Liang R., Chen C-J., Florida State University, US

Carbon nanotubes are emerging as potential tools in drug delivery nanocarriers to target specific cell types and carbon cages filled with metal molecules and may improve MRI microimaging. The present paper reviews the current state [...]

Fate, Transport, and Toxicity of Nanomaterials in Drinking Water

Zhang Y., Koeneman B.A., Chen Y., Westerhoff P., Capco D.G., Crittenden J., Arizona State University, US

The objective of this research is to evaluate the potential risk of human exposure to nanomaterials in drinking water by examining three issues: 1) characteristics and stability of nanomaterials in the water environment; 2) removal [...]

Cell-based Assays for Cytotoxic and Pro-inflammatory Effects of Gold Nanoparticles

Knight T., Wise S.S., Wise_Sr. J.P., Mason M.D., Wise_Sr. J.P., Ng A-K., University of Southern Maine, US

This study aims at developing cell-based assays to assess the potential cytotoxic and proinflammatory effects of nanomaterials, using 15 nm gold nanoparticles as a model. In a MTT cytotoxicity assay, significant cytotoxicity was found in [...]

Differential Cytotoxicity of Metal Oxide Nanoparticles

Chen J., Zhu J., Cho H.-H., Cui K., Li F., Zhou X., Rogers J.T., Wong S.T.C., Huang X., Brigham and Women's Hospital, Harvard Medical School, US

There are growing concerns among the general public and regulators about their potential health hazard. To determine the potentially toxic responses of CNS due to exposure of metal oxide nanoparticles, human SH-SY5Y neuroblastoma and H4 [...]

Biodistribution and Toxicity of Nanomaterials In Vivo: Effects of Composition, Size, Surface Functionalization and Route of Exposure

Harper S.L., Maddux B., Hutchison J., Tanguay R.L., Oregon State University, US

Given the anticipated growth of the nanotechnology industry and the deficiency of toxicological information, there is an obvious need for rapid, relevant and efficient testing strategies to evaluate the biological activity and toxic potential of [...]

An integrated NMR/nanosensor system for sensitive detection of environmental toxins and harmful microbes

Perez J.M., Fries D.P., Hickman J.J., University of Central Florida, US

The use of nanoparticles and NMR detection technologies has lead to significant improvements in sensitivity. Nanoparticles have many useful optical and electronic properties derived from their small size. When coupled to affinity ligands, these materials [...]

Stable Isotope Tracing – a way forward for Nanotechnology?

Gulson B., Wong H., McCall M., Danon S., Greenoak G., Trotter J., Casey P., Stauber J., Commonwealth Scientifc and Industrial Research Organisation, AU

Numerous publications and reports have expressed health and safety concerns about the production and use of nanoparticles, especially in areas of exposure monitoring, personal use, and environmental fate and transport. We suggest that stable isotopic [...]

Toxicogenomics study of nanomaterials on the model organism zebrafish

Rojo I., Uriarte M., Obieta I., Bustero I., Egizabal A., Pardo M.A., Martínez de Ilárduya O., Azti-Tecnalia, ES

The applications of nanomaterials include fields as biomedicine, cosmetics or food science, raising a concern about the need to determine their toxic effects. Most of the toxicity tests are based on the analysis of classical [...]