Sector: Medical & Biotech
Electrospun Microfiber Tubes and Self-Assembling Peptides Stimulate Neural Regeneration in Rat Sciatic Nerve Transections
Gelain F., Panseri S., Modica L., Taraballi F., Lowery J., Vescovi A., University of Milan-Bicocca, IT
Peripheral nerve injury is still a traumatic pathology that may impair patient’s movements by interrupting his motor-sensory pathways. New synthetic nerve grafts comprising electrospun tubes and tailored self-assembling peptides are used in our study to [...]
Using Chondroitin Sulfate to Synthesize Nanoparticles
Vercruysse K.P., Williams A., Ivory D., Johnson B., Dixon R.D., Tran M.T., Moore J.T., Tennessee State University, US
We provide evidence that chondroitin sulfate (CS), a member of the glycosaminoglycan (GAG) family of polysaccharides found in the extracellular matrix of all higher order species, can be used as a matrix to generate nanosized [...]
In vitro & in vivo toxicity of CoFe2O4 nanoparticles for application to magnetic hyperthermia
Kim D-H., Kim K-M, Kim K.N., Kim D-H., Kim K-M, Kim K.N., Kim D-H., Kim K-M, Kim K.N., Shim I-B, Lee Y.K., The University of Alabama, Tuscaloosa, US
Magnetic nanoparticles offer some attractive possibilities in biomedicine because it has the special physical properties. So, we can usually consider four particular applications: magnetic separation, drug delivery, hyperthermia treatments and magnetic resonance imaging (MRI) contrast [...]
Nano-Surface Behavior of Osteoblast Cell-Cultured Ti-30(Nb,Ta) with Low Elastic Modulus
Ti and Ti-alloys have good biocompatibility, appropriate mechanical properties and excellent corrosion resistance. However, the widely used Ti-6Al-4V is found to release toxic ions (Al and V) into the body, leading to undesirable long-term effects. [...]
Silicon Dioxide Nanoparticles Can Exert Cytotoxic Effects on Neural Cells
Lai J.C.K., Lai M.B., Lai J.C.K., Lai M.B., Edgley K.L., Bhushan A., Dukhande V., Daniels C.K., Leung S.W., Idaho State University, US
The health risk and cytotoxic effects of nanoparticles are almost unknown. Consequently, we have launched an interdisciplinary research program to systematically investigate the toxicity of nanoparticles. An initial observation prompted us to hypothesize that SiO2 [...]
Integration of Living Cells with Silicon Microstructures for MEMS Applications
Molnar P., Bhargava N., Das M., Natarajan A., Wilson K., Hickman J.J., University of Central Florida, US
For many years biological and silicon-based structures were considered incompatible because of the difficulties to engineer an effective interface connecting the two systems. Recent developments in surface chemistry, bioengineering and cell biology enabled the creation [...]
Diffusion of Nanoparticles through the Tissues in Experiment
Reshetov I.V., Frank G.A., Sukharev S.S., Efremov G.D., Danileico Yu.C., Timoshenko V.Yu., P.A.Hertzen Moscow Research Oncological Institute (MROI), RU
We have created nanocrystals of silicon with sizes in the greatest measurement in the average 50 nm (from 4 to 100 nm), and nanocrystals of the oxide of aluminum with the adsorbed molecules of phthalocyanines, [...]
Nanotopography-controlled Cell Life and Death
NIH-3T3 cells were grown on nanodot arrays to investigate how cells respond to nanolandscape. The nanodot arrays consisted nanodot of diameters ranging from 10 to 200 nm which were fabricated by AAO processing on Ta-coated [...]
Effects of Zr Content on the Electrochemical Characteristics of Nano-Structure Controlled Ti-alloys
Objective: Pure Ti as well as Ti-6Al-4V alloy exhibit excellent properties for dental implant applications. However, for a better biocompatibility it seems important to avoid in the composition the presence of V due to the [...]