Medical & Biotech – Page 116 – TechConnect Briefs

Biomolecular activity switch: an application of metallic nanoparticle plasmon resonance

Alper J., Wijaya A., Crespo M., DeFlores L., Tokmakoff A., Hamad-Schifferli K., Massachusetts Institute of Technology, US

Specific external control of biomolecular activity is a critical step in harnessing the power of nature’s molecular machinery. We propose and demonstrate one control method, a biomolecular activity switch. Since proteins are the primary macromolecule [...]

2-Nitroimidazole as Potential Nanoprobe in Hypoxia Imaging by MRI/PET

Sharma A., Sharma R., Sharma A., Sharma R., University of North Carolina, US

2-Nitroimidazole is radiosensitizer and serves as imaging contrast agent by 19F- and 31P MR methods. Despite the success of mesonidazole and SR-4554 compounds, very little is known of its hepato-cytotoxicity if it can be potential [...]

Multiplexed Proteolytic Enzyme Assay Based on Energy Transfer between Quantum Dots and Gold Nanoparticles

Oh Y.H., Kim H-S, Kim Y.P., Kim H-S, Kim Y.P., Korea Abvanced Institute of science and Technology, KR

Proteases are key enzymes that regulate both normal and malignant tumor progress. Evaluating these enzymes and their inhibitors, therefore, has a great potential to diagnostics or therapeutic treatment against specific diseases or disorders. We have [...]

Towards nanosized particles in pharmaceutical industry

Bieri N.R., Meier U., Goncalves E., Zimmermann D., Juhnke M., Thakur R., Novartis Pharma AG, CH

The pharmaceutical industry is facing the problem of an increasing number of drug substances in development which are either poorly water soluble or show pH dependency of solubility. Drug targeting and tailored delivery poses additional [...]

Nanomaterial: A realistic business case for Pharma

Keller T.H., GlaxoSmithKline, UK

Main points from a pharma perspective: Review nanotech’s current position Nanotech and its realistic potential Nanotech and the barriers into the clinic GSK’s position on the subject matter

Effect of Medical Device Substrate Material on Nanoparticulate Silver Efficacy

Dair B.J., Kennedy K.M., Casas R.S., FDA, US

Silver is one of the oldest known natural antimicrobial materials, the active form being the Ag+ ion, which disrupts critical cell functions in bacteria. Reducing the size of silver particles to the nano-scale regime increases [...]

Biomarkers, Nano Particles & Materials

Spatio-temporal Tumor Model for Analysis and Mechanism of action of Intracellular Drug Accumulation

Mishra S., Katiyar V.K., Arora V., Haridwar, IN

We have developed a one-dimensional tumor simulator to describe the biodistribution of chemotherapeutic drugs to a tumoral lesion and the tumor cell’s response to therapy. A three-compartment model is used for drug dynamics within the [...]

Upconverting nanoparticles for photodynamic therapy

Chatterjee D.K., Zhang Y., National University of Singapore, SG

Photodynamic therapy involves killing of diseased cells by excitation of photosensitizer chemicals with high energy light to produce cytotoxic oxygen species from surrounding dissolved oxygen. However, poor tissue penetration of high energy light and hydrophobic [...]

Pharmacokinetic study of PEGylated plasmon resonant gold nanoparticles in tumor-bearing mice

Kogan B.Ya., Andronova N.V., Khlebtsov B.N., Khlebtsov N.G., Khlebtsov B.N., Khlebtsov N.G., Rudoy V.M., Dement’eva O.V., Sedykh E.M., Bannykh L.N., FGUP “GNC “NIOPIK”, RU

Gold nanorods and gold nanoshells have been synthesized. Nanorods have length of 50 nm, diameter of 15-20 nm. Nanoshells have 80 nm silica core diameter with 25 nm thick gold shells. Then poly(ethylene glycol) molecules [...]