Papers – Page 15 – TechConnect Briefs

Air Powered Artifical Lungs and other High Efficiency Fluid Reactor Innovations

Strobl K., Gainey S., Kumar A., Kumar A., CVD Equipment Corporation, US

Commercially available Hollow Fiber (HF) based Extracorporeal Membrane Oxygenators (ECMO) are presently being built using a parallel assembly of over 10- 20K of porous hollow polymeric fibers as respective reactor core elements (RCE). They are [...]

A Biomedical Sensor Based on Resonant Absorption of Ultrasound Waves in Hydrogel-based Resonators

Farhoudi N., Leu H-Y, Magda J., Solzbacher F., Reiche C.F., University of Utah, US

Smart hydrogels can be tailored to undergo a vol- ume change in response to an analyte. The potential biocompatibility of these materials has made them a very promising material for biomedical sensing applica- tions. To [...]

M2D2: a successful model catalyzing medical device innovation and development

Hafer N., McManus D., Picard M., Tello, S., University of Massachusetts Center for Clinical and Translational Science, US

The Massachusetts Medical Device Development (M2D2) center offers inventors and small medical device companies coordinated access to research, engineering, and clinical investigation at the UMass Medical School (UMMS) and UMass Lowell (UML) campuses. UMMS provides [...]

Personalized nanomedicine for the treatment of vascular hypertension in polycystic kidney disease models

Pala R., Nauli S.M., University of California Irvine, US

In our current study, we designed a nanomedical device for the treatment of vascular hypertension in polycystic kidney disease (PKD) model through cilia targeting. We generated and compared two different metal and polymer cilia-targeted nanoparticle [...]

Enhancement of Effects of Chitosan and Nanoparticles on Pancreatic Cancer Cells by Combination Treatments with the Anti-Cancer Drug Adriamycin

Lai J.C.K., Gao W., Bhushan A., Leung S., Idaho State University College of Pharmacy, US

Because of chitosan’s roles in biomedical applications, this study investigated the effects of chitosan, chitosan in combination with silver or gold nanoparticles, and chitosan with nanoparticles and Adriamycin, Methotrexate or Cisplatin on human PANC-1 pancreatic [...]

Cytotoxic Effects of Short Multi-Wall Carbon Nanotubes on Pancreatic Cancer Cells

Lai J.C.K., Desai V., Zhang Y., Bhushan A., Leung S., Idaho State University College of Pharmacy, US

Although carbon nanotubes (CNTs) are increasingly exploited in diverse industrial and biomedical applications, their health hazard to humans is poorly understood. We have developed many cell models in vitro to systematically study the putative cytotoxicity [...]

Discriminated properties of PEI functionalized gold nanoparticles (Au-PEIs) predetermined by synthetic routes of ligand exchange and reduction processes: Paths and Fates

Cho T.J., Gorham J.M., Pettibone J.M., Hackley V.A., National Institute of Standards and Technology, US

Polyethyleneimine (PEI) functionalized AuNPs (Au-PEIs) have potential use as positively charged gold nanoparticles (AuNPs) for nano-medicinal applications, due to their cationic surfaces that promote cellular uptake and gene transfection.1-6 Au-PEIs can be prepared by one [...]

Accelerated Neutral Atom Beam processing of medical devices enhances tissue integration while reducing bacterial attachment

Khoury J., Phok B., Kirkpatrick S., Walsh M., Shashkov D., Exogenesis Corp, US

Accelerated Neutral Atom Beam (ANAB) technology is a low energy accelerated particle beam gaining acceptance as a tool for nano-scale surface modification of implantable medical devices. ANAB is created by acceleration of 2. METHODS neutral [...]

Remote control of mechano-sensory function of primary cilia by Fe2O3 nanoparticles in ciliopathic animal models

Pala R., Nauli S.M., Chapman University and University of California Irvine, US

In the present studies, we designed a cilia-targeted delivery system to deliver fenoldopam (FD) specifically to the primary cilia. Hence, we devised the iron oxide nanoparticle (Fe2O3-NP)-based technology for ciliotherapy. Dynamic light scattering measurements showed [...]

Bacteria Inhibitory Action of Peptides P753 and P359 in 2D and 3D Cell Cultures

Masuda J., Vig K., University of Hawaii at Manoa, US

The current study investigated two proprietary peptides, p359 and p753, for their antibacterial activity against Escherichia coli (E.Coli) and Staphylococcus aureus (S. aureus). Minimum Inhibitory Concentration (MIC) of bacteria for p359 and p753 was 50μg/mL [...]