toxicity – TechConnect Briefs

Effects of III-V Semiconductor Nanowires on Human Lung Cancer Cells

Abariute L., Prinz C.N., Lund University, SE

Nanotechnology empowers existing technologies and enriches the effectiveness of new applications. One of the great examples are III-V semiconductor nanowires (NW), which have a broad application range, from electronics and energy-conversion to biological applications [1]. [...]

Enhanced in vitro testing model for rapid risk assessment of ingested nanomaterials

Barone F., Carnovale C., De Angelis I., Guarnieri D., Sabella S., Italian Institute of Technology, IT

Following advances in the synthesis of manufactured nanomaterials, interest for their inclusion in various consumer products has increased. Due to various factors including their unique optical and antimicrobial properties, likely applications of nanomaterials include textiles, [...]

Nanotechnology Regulation Implementation in Industry

Freeman E.L., Taylor A.A., Exponent, Inc., US

Nanotechnology is a fast growing industry with increasing applications in consumer, industrial, pharmaceutical, and personal care products. One issue facing the nanotechnology sector is that current chemical regulations focus on single chemical substances and do [...]

Assessment by Ames Test and Comet Assay of Toxicity Potential of Polymers Used to Develop a Field Capable Biosensor

Gleason K., Hebert A., Torosian S., Food and Drug Adminstration, US

Current methods of detecting food-borne pathogens take days to show and confirm results. There is a need for devices that decrease detection time. A field-capable rapid-detection device is being developed and in this study it [...]

Gaining critical mass: A dose metric conversion study using silver nanoparticles

Bednar A., Bednar A.J., Chappell M., Diamond S., Hull M.S., Kennedy A.J., Steevens J.A., US Army Engineer Research and Development Center, US

Mass is still the standard dose metric applied in the nano(eco)toxicology literature. Greater particle surface area or number may be more relevant dose metrics than mass to represent particle interactions with biological surfaces. This investigation [...]

Assessment by Ames Test and Comet Assay of Toxicity Potential of Polymers Used to Develop a Field Capable Biosensor

Gleason K., Hebert A., Torosian S., Food and Drug Adminstration, US

Current methods of detecting food-borne pathogens take days to show and confirm results. There is a need for devices that decrease detection time. A field-capable rapid-detection device is being developed and in this study it [...]

Toxic Potential of Food-Relevant Nanoparticles in the Intestinal Epithelium

Dutta P., Knight D., McCracken C., Waldman W.J., Zane A., The Ohio State University, US

Oral exposure to nanoparticles incorporated in foods is increasingly common. However, the effects of these nanoparticles when ingested are still unknown. Thus, this investigation tested the hypothesis that nanoparticle toxicity is dependent on particle size, [...]

Iron-sequestering molecules play a pivotal role in the mechanism of toxicity of SWNTs on fungal and bacterial cells

Chaves J.S., Chaves S.J., Zuniga P., Instituto Tecnologico de Costa Rica, CR

In this study we described that iron-sequestering molecules are responsible for the toxicity of iron containing SWNTs to microorganisms. After incubating different concentrations of functionalized SWNTs with bacteria and fungal cells, it was found that [...]

Evidence for a direct interaction between poly-dispersed single-wall carbon nanotubes and murine erythrocytes resulting in in vitro and in vivo cytotoxicity

Sachar S., Saxena R.K., Jawaharlal Nehru University, IN

Single wall Carbon Nanotubes (SWCNTs) are highly hydrophobic in nature and agglomerate strongly. Treatment of SWCNTs with sulphuric and nitric acid (acid functionalization) results in the introduction of carboxy and sulfonate groups on SWCNTs and [...]

Assessment of release and toxicity of NP from silicon-based polymer composites in a life cycle perspective

Irfan A., Njuguna J., Sachse S., Zhu H., Cranfield University, UK

Nanomaterial integration in public domain raises concerns regarding human health impact. This study examines the possibility of nanoparticle release from new engineered nanocomposites, using real life scenarios in life cycle analysis approach. Physical and biological [...]